There are different formulations of melatonin, which is the best to be bought?
Professor Walter Pierpaoli is probably the first researcher of melatonin in the world.
Melatonin (N-acetyl-5-methoxytryptamine) is a natural substance of pineal gland (hypophysis) present in all the living shapes.
melatonin comes from vegetables and it is extracted from cacao.
It acts directly on sleep. It is a natural substance that determines the cycle sleep waking in sure way.
It has to be assumed possibly half an hour before sleep; every night at the same time to re-establish the circadian cycle (1 tablet every evening).
Zinc is one of the essential components, among the 200 enzymes in the body and one of the most relevant trace elements.
Dr. Pierpaoli Melatonina expresses the best imaginable melatonin preparation, now available as food additive and dietary supplement for anyone who wants to take advantage from this product which comes from the extraordinary scientific observations of various researchers.
Selenium is a fundamental trace element of the body too and has powerful anti-cancer effects.
Modern agriculture and alimentary habits have dramatically decreased the daily input of selenium from the diet. Selenium is essential for the enzymatic reaction responsible of the synthesis of glutathione, a powerful physiological molecule which constantly protects the body from oxidative damage.
Lack of selenium provokes a loss of the detoxication capacity of the body, immunodepression and onset of degenerative diseases and cancer.
The result is normalization of all measurable immunological and endocrine functions.
Contraindications and general suggestions:
Melatonin should not be given to healthy children, pregnant women and lactating mothers unless it is specifically prescribed by a physician.
There is no evidence that Melatonin could adversely influence the effects and activity of estrogens. On the contrary, melatonin increases the density of estrogen receptors in sensitive target tissues (mammary gland, womb, ovaries, etc.) and greatly improves their actions. There are no contraindications for dietary supplements containing melatonin, zinc and selenium.
Melatonin must be taken late in the evening at bedtime in order to mimic and restore the physiological night peak, which normally declines progressively during the course of aging.
Melatonin does not induce sleep but facilitates it and produces a sleep pattern, typical of children or young people.
It greatly improves the quality of sleep and it restores physical and psychological effects, with a clear improvement of morning mood and body muscle strength.
Melatonin is not a drug and it is not a cure for any disease!
Melatonin is ubiquitous in nature, cells, plants, animals, tissues and any living organism.
Milk, vegetables, cereals, rice, meat, etc., contain variable amounts of melatonin.
Melatonin cannot be considered as a classical “hormone,” although it is so-named. It does not possess any of the qualities of the classical hormones like growth hormone, cortisol, estrogens, thyroid hormones etc. It is rather a chemical mediator whose mechanism is still unknown. It modulates and controls the synthesis and secretion of all hormones within a circadian and seasonal periodicity and variability. It has been given at a huge dosage of grams daily for prolonged periods, and to 1500 women at the daily dosage of 300mg for years with no observed late side-effects and consequences.
The beneficial effects of melatonin in the
normalization of zinc levels have been
scientifically proved and constitute a basic tool
for maintenance of hormonal and immune functions and
for restoring of these functions during aging.
Daily dosages suggested for a dietary supplement:
Between 40 and 50 years of age: 1.5mg to 1 mg at bedtime (preferably at the same hour, with half an hour of tolerance).
After 50 years until 75 years of age: 1 mg at bedtime as above.From 75 years of age: 3-6mg at bedtime as above.
Pro Vision Pierpaoli
Provision is a excellent formulation Dr. Pierpaoli and it is useful for eyes health.
PRO VISION 60 tablets : Lutein 6mg, Vitamin A , Black blueberry 50mg, Vitamin E, Glutation 5mg, Selenium, Melatonin 1 mg, Zinc 100%.
W. and Regelson W. with Carol Colman, “The Melatonin Miracle”, Simon &
W. The pineal gland: a circadian or a seasonal aging clock? Aging 3:
Pierpaoli, W. Dall’Ara, A, Pedrinis, E. and Regelson, W. The pineal control of aging. The effects of melatonin and pineal grafting on the survival of older mice.
W., and Lesnikov, V.A. The pineal aging clock. Evidence, models, mechanisms,
interventions. The Aging Clock. Third Stromboli
Conference on Agingand
W. and Regelson, W. Pineal control of aging: effect of melatonin and pineal
Mocchegiani, E., Bulian,
D., Santarelli, L., Tibaldi, A., Muzzioli, M., Pierpaoli, W. and
Fabris, N. The immuno-reconstituting effect of melatonin or
pineal grafting and its
Mocchegiani, E., Bulian,
D., Santarelli, L., Tibaldi, A., Muzzioli, M., Lesnikov, V., Pierpaoli,
Mocchegiani, E., Bulian, D., Santarelli, L., Tibaldi, A., Pierpaoli, W. and Fabris, N. The zinc-melatonin interrelationship. A working hypothesis. The Aging Clock.
Third Stromboli Conference on Aging and Cancer, June 1993.
Ann. N.Y. Acad. Sci. 719: 298-307. 1994.
Fabris, N. Neuroendocrine-immune aging: an integrative view on the role of zinc. The Aging Clock. Third Stromboli Conference on Aging and Cancer, June 1993.
Ann. N.Y. Acad. Sci.
Meister, A. and Anderson, M.E. Glutathione. Ann. Rev. Biochem. 52: 711-760, 1983.
W. and Lesnikov, V.A. Theoretical considerations on the nature of the pineal
“aging clock”. Gerontology 43: 20-25, 1997.
G., Bianchi. P, Pierpaoli, W., Bulian, D. and Ilyia, E.
Effects of melatonin in perimenopausal and menopausal
women. A randomized and placebo
controlled study. Exp. Gerontol. 36,
Pierpaoli, W. and Lesnikov, V.A. Theoretical considerations on the nature of the pineal “aging clock”. Gerontology 43, 20-25, 1997. Bellipanni, G., Bianchi, P., Pierpaoli, W., Bulian, D. and Ilyia, E. Effects of melatonin in perimenopausal and menopausal women: a randomized and placebocontrolled study. Exp. Gerontol., 36, 297-310, 20