|1: Ann N Y Acad Sci. 1994 May 31;719:456-60.
Pineal cross-transplantation (old-to-young and vice versa)
as evidence for an endogenous "aging clock".
Lesnikov VA, Pierpaoli W.
Institute of Experimental Medicine, Russian Academy of Medical Science, St.
Circadian (night), chronic administration of melatonin and young-to-old pineal
grafting into the thymus have provided evidence for the existence of an
endogenous, primary and central "aging clock" in the pineal gland. The new
model described here serves to definitely demonstrate that the replacement of
the pineal gland of an old mouse with the pineal from a young, syngeneic donor
mouse remarkably prolongs its life and, conversely, the "old" pineal
transplanted into a younger mouse will considerably shorten its life span.
Pineal cross-transplantation thus provides clear-cut evidence for the central
role of the pineal gland in the initiation and progression of senescence. It
offers a novel basis for interventions in the aging process.
PMID: 8010614 [PubMed - indexed for MEDLINE]