STENDRA (avanafil)

Stendra: oral treatment for male impotence and erectile dysfunction

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Chemical Stendra Avanafil
Avanafil is a PDE5 inhibitor approved for erectile dysfunction on April 27, 2012.

Avanafil is known by the trademark name Stendra and was developed by Vivus Inc.

It acts by inhibiting a specific phosphodiesterase type 5 enzyme which is found in various body tissues, but primarily in the corpus cavernosum penis, as well as the retina.

Other similar drugs are sildenafil, tadalafil and vardenafil.

The advantage of avanafil is that it has very fast onset of action compared with other PDE5 inhibitors.

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Stendra causes the expansion of blood vessels in the penis, allowing blood to enter the penis and the formation of an erection to occur.

The drug gets into work within fifteen minutes.

This drug should not be used by people who take nitrates, commonly used for chest pain because a combination of these can cause a sudden drop in blood pressure.

Stendra is the only drug in the last decade to be given approval by the FDA for the treatment of male impotence.

Stendra will be quicker to act and requires a full of 30 minutes for effectiveness and in 15 minutes it would be a significant improvement.

Stendra comes in dosages of 50mg, 100mg and 200mg and this is the new drug for erectile dysfunction.

For most of the patients stendra starting dose is 100mg and should be approximately taken 30 minutes before sexual activity and should not be taken more than once per day.

Stendra Avanafil is a new PDE5 inhibitor indicated for erectile dysfunction treatment available under prescription on the market.

Stendra can cause side effects such as flushing, runny nose, stuffy nose, sore throat and back pain.

Several clinical trials have demonstrated that it acts much faster than any leading ED medication currently on the market .

Out of thousands of men who participated in these trials, a large percentage reported firm erections with-in 15 minutes after taking it.

The success rate is calculated at 77% and it is becoming known as the fastest pill available.

Stendra resulted in successful intercourse for 57% of men with general ED (vs. 27% of men taking placebo) and for 40% of men with diabetes-related ED (vs. 20% of men taking placebo).

The main side effects of avanafil are similar to those of its sister drugs: headache, flushing, stuffy nose, and back pain.

Rarely, an erection lasting for four or more hours may occur, which would need immediate medical attention.

Other side effects occurring rarely include color vision changes, sudden loss of vision, and sudden loss of hearing.

If sudden loss of vision or hearing occurs, it is recommended to call a doctor immediately.

Men who take nitrate medications should not take Stendra because the combination of these two medications can lead to a sudden drop in blood pressure.

 

REFERENCES

FDA Stendra approval.

 

J Sex Med. 2012 Apr;9(4):1122-33. doi: 10.1111/j.1743-6109.2011.02629.x. Epub 2012 Jan 16.

A randomized, double-blind, placebo-controlled evaluation of the safety and efficacy of avanafil in subjects with erectile dysfunction.

Goldstein I, McCullough AR, Jones LA, Hellstrom WJ, Bowden CH, Didonato K, Trask B, Day WW.

 

Drugs Today (Barc). 2012 Jan;48(1):7-15.

Avanafil for the treatment of erectile dysfunction.

Segal R, Burnett AL.

 

BJU Int. 2012 Mar 27. doi: 10.1111/j.1464-410X.2012.11095.x. [Epub ahead of print]

Efficacy and safety of avanafil for treating erectile dysfunction: results of a multicentre, randomized, double-blind, placebo-controlled trial.

Zhao C, Kim SW, Yang DY, Kim JJ, Park NC, Lee SW, Paick JS, Ahn TY, Moon KH, Chung WS, Min KS, Suh JK, Hyun JS, Park K, Park JK.

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