Bibliografia degli studi scientifici del Prof. Pierpaoli su relazione tra melatonina e cancro

Pace,G.,Pierpaoli,W.e Clerici, E.Aerobic glycolysis of normal tissues suspended in thoracic  duct lymph. Experientia 23, 63, 1967.
Pierpaoli, W. e  Sorkin, E.  Relationship between thymus and hypophysis. Nature 215, 834, 1967.
Pierpaoli, W. and Sorkin, E. Effect of gonadectomy on the peripheral lymphatic tissue of neonatally     thymectomized mice. Brit. J. exp. Path. 49, 288, 1968.
Pierpaoli, W. and Sorkin, E. Hormones and immunological capacity. I. Effect of heterologous anti-growth hormone (ASTH) antiserum on thymus and peripheral lymphatic tissue in mice. Induction of a wasting syndrome. J. Immunol. 101, 1036, 1968.
Pierpaoli, W. and Sorkin, E. A study on anti-pituitary serum. Immunology 16, 311, 1969
Pierpaoli, W., Fabris, N. and Sorkin, E. Developmental hormones and immunological maturation. In: Hormones and the Immune Response, Ciba Foundation Study Group No. 36. G.E.W.Wolstenholme and Julie Knight, editori. Churchill, London, pp 126-143, 1970.
Pierpaoli, W. and Sorkin, E. Immunological blockade of the adenohypophysis and its possible application to prophylaxis and therapy of neoplasia. Experientia 28, 336, 1972.
Pierpaoli, W. and Sorkin, E. Specificity and properties of anti-adenohypophysis serum. Mode of preparation, titration and effects of neonatal injection into rats. Clin. exp. Immunol. 11, 427, 1972
Pierpaoli, W. and Sorkin, E. Inhibition of growth of methylcholanthrene (MC)-induced mammary      carcinoma by anti-adenohypophysis (anti-AH) serum. Nature New Biology 238, 58, 1972.
Pierpaoli, W. and Sorkin, E. Alterations of adrenal cortex and thyroid in mice with congenital      absence of the thymus. Nature New Biology 238, 282, 1972.
Fabris, N., Pierpaoli, W. and Sorkin, E. Lymphocytes, hormones and aging. Nature 240, 557, 1972.
Pierpaoli, W., Haran-Ghera, N., Bianchi, E., Mueller, J., Meshorer, A. and Bree, M. Endocrine   disorders as a contributory factor to neoplasia in the SJL/J strain of mice. J. Natl. Cancer Inst.     53, 731, 1974.
Pierpaoli, W. and Haran-Ghera, N. Prevention of induced leukemia in mice by immunological     inhibition of adenohypophysis. Nature 254, 334, 1975.
Pierpaoli, W. and Besedovsky, H.O. Role of the thymus in programming of neuroendocrine      functions. Clin. Exp. Immunol. 20, 323, 1975.
Pierpaoli, W., Haran-Ghera, N. and Kopp, H.G. Role of the host endocrine status in murine      leukemogenesis. Brit. J. Cancer 35, 621, 1977.
Pierpaoli, W. Changes of the hormonal status in young mice by restricted caloric diet. Relation to    lifespan extension.Preliminary results. Experientia 33, 1612, 1977.
Pierpaoli, W. and Maestroni, G. Drug-induced chimerism and prevention of graft versus-host     disease in lethally irradiated mice transplanted with rat bone marrow. Transplantation 26, 456, 1978.
Pierpaoli, W. and Maestroni, G.  and Sache, E. Enduring allogeneic marrow engraftment via non-specific bone marrow-derived regulating factor (MRF).Cell. Immunol. 57, 219, 1981.
Pierpaoli, W. and Meshorer, A. Host endocrine status mediates oncogenesis: leukemia  virus-     induced carcinomas and reticulum cell sarcomas in acyclic or normal mice. Europ. J. Cancer 18,     1181, 1982.
Pierpaoli, W. and Maestroni, G. Dominance and persistence of donor marrow in long-lived      allogeneic radiation chimeras obtained with unmanipulated bone marrow. Immunol Let.6,197, 1983.
Pierpaoli, W. Growth of transplantable melanoma and leukemia and prevention of virus-induced     leukemia in long-lived radiation chimeras constructed with unmanipulated bone marrow.     Clin. and Exp. Immunol. 59, 210, 1985.
Pierpaoli, W. Neuroimmunomodulation: an approach to the therapy of neurological diseases. In:Clinical Neuroimmunology, J.A. Aarli, W.M.H. Behan and P.O. Behan, editori.  Blackwell,     Oxford, pp 500-505, 1987
.Regelson, W. and Pierpaoli, W. Melatonin: a rediscovered anti-tumor hormone? Its relation to surface receptors; sex steroid metabolism; immunological response and chronobiologic factors in tumor growth and therapy. Cancer Investigations 5, 379, 1987.
Pierpaoli, W. and Maestroni, G. Melatonin: a principal neuroimmunoregulatory and anti-stress hormone: its anti-aging effects. Immunol. Let. 16, 355, 1987.
Pierpaoli, W., Balakrishnan, J. Maestroni, G., Sache, E. and Choay, J.  Bone marrow: a     "morphostatic brain" for control of normal and neoplastic growth. Experimental evidence.In:Neuroimmunomodulation: Interventions in Aging and Cancer. Ann. N.Y. Acad. Sci.521, 300, 1988
 (First Stromboli Conference on Aging and Cancer). Pierpaoli, W., Yi, C.X. and Dall'Ara, A. Aging-postponing effects of circadian melatonin:experimental evidence, significance and possible mechanisms. Int. J. Neurosci. 51, 339, 1990.
Pierpaoli, W. The pineal gland: a circadian or seasonal aging clock? Aging 3, 99, 1991.
Pierpaoli, W. and Regelson, W. The pineal control of aging. The effect of melatonin and pineal grafting on aging mice. Proc. Natl. Acad. Sci. USA, 91, 787, 1994.
Mocchegiani, E., Bulian, D., Santarelli, L., Tibaldi, A., Muzzioli, M. Pierpaoli, W. and Fabris, N.The immuno-reconstituting effect of melatonin or pineal grafting and its relation to zinc pool in     aging mice. J. Neuroimmunol. 53, 189, 1994.
Pierpaoli, W. The pineal gland as ontogenetic scanner of reproduction, immunity and aging.      In: Neuroimmunomodulation; The State of the Art. Ann. N.Y. Acad. Sci. 741, 46, 1994.
Deeg, H.J., Pierpaoli, W., Arrighi, S., Seidel, K., Graham, T., Huss, R., Yu, C., Myerson, D.,      Schuening, F. and Storb, R. Facilitation of DLA-incompatible marrow grafts by donor-specific serum transferrin? Transplant Immunol. 4, 113, 1996.
Pierpaoli, W., Lesnikov, V.A., Lesnikova, M.P., Arrighi, S. and Bardotti, A. Specific xenogeneic     (human) tolerance in immunosuppressed mice by combined donor-derived human transferrin     and antigens. Transpl. Proc. 28, 711, 1996.Pierpaoli, W., Lesnikov, V.A., Lesnikova, M.P. and Arrighi, S. Donor-derived plasma transferrin     facilitates the engraftment of xenogeneic (rat) bone marrow in irradiated mice. Bone Marrow     Transplantation 18, 203, 1996.
Pierpaoli, W., Lesnikov, V.A., Lesnikova, M.P., Arrighi, S. and Bardotti, A. Unresponsiveness     to human leukocytes in immunosuppressed mice by combined donor-derived human transferrin     and antigens. Transpl. Immunol. 4, 301, 1996.
Pierpaoli, W. and Lesnikov, V.A. Theoretical considerations on the nature of the pineal "aging  clock".Gerontology 43, 20, 1997
Bulian, D. and  Pierpaoli, W. The pineal gland and cancer. I. Pinealectomy corrects congenital    hormonal dysfunctions and prolongs life of cancer-prone C3H/He mice.  J. Neuroimmunol.    108, 131, 2000.

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