KETOCONAZOLE
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It is an antifungal medicine of synthesis.

It is used for serious forms of micosi by oral use.

It is also a bland antiandrogen.

It is one of the good medicines for the seborroic dermatitis, seborrea, the dandruff, fat hair and good generally in the therapy of the micosis.

Studies affirm that it is not absorbed systematically when it is used externally.

With precision it stops the citocromo P 450 and all the enzymes that depend on it.

Women have levels of citocromo  P 450 aromatasis in the skin around the follicle 6 great turns of the man.

The levels of this enzyme could explain why in women androgenetica baldness proceeds in a less aggressive manner.

This enzyme metabolizes the androgens in estrogens.

The U.S. Food and Drug Administration (FDA) has approved its new drug application for Extina (R) (ketoconazole) Foam, 2% for the treatment of seborrheic dermatitis.

Different from other treatments for seborrheic dermatitis, which contain ketoconazole 2% in a cream, gel or shampoo vehicle, Extina is administered using VersaFoam(R) HF(R) (hydroethanolic formulation) technology, a unique, versatile topical drug delivery vehicle that is quickly absorbed into the skin. Extina Foam proved to be superior to placebo foam in a Phase III clinical trial. Of subjects receiving Extina (R) Foam, 56% achieved treatment success based on an Investigator Global Assessment compared to 42% of subjects receiving vehicle foam. Stiefel Laboratories, the world’s largest independent pharmaceutical company specializing in dermatology, acquired the proprietary VersaFoam HF technology with its December 2006 acquisition of Connetics Corporation.

Extina should be applied to the affected skin areas twice a day (morning and evening) for four weeks. Extina is administered via VersaFoam HF, which studies show offers consistent skin permeation, drug distribution and drug delivery. Additional patient benefits include versatility (Extina can be used on hair bearing and non hair-bearing skin), it absorbs quickly and it is non-drying with no residue.

Ketokonazole is the active ingredient in Nizoral shampoo and is used by many hair loss sufferers because studies have shown that it’s beneficial in treating hair loss.

Scientific studies
Ketoconazole shampoo: effect of long-term use in androgenic alopecia
7-Ethoxyresorufin-O-deethylase activity in human hair roots: a potential marker for toxifying species of cytochrome P-450 isozymes
Ketoconazole binds to the human androgen receptor
Hydroxylation of 5 alpha-androstane-3 beta,17 beta-diol by rat prostate microsomes: potent inhibition by imidazole-type antimycotic drugs and lack of inhibition by steroid 5 alpha-reductase inhibitors
4-pregnene-3-one-20 beta-carboxaldehyde: a potent inhibitor of 17 alpha-hydroxylase/C17,20-lyase and of 5 alpha-reductase
Transcutaneous absorption of ketoconazole in infant after application of Ketoderm
Clinical pharmacokinetics of ketoconazole
P450-dependent enzymes as targets for prostate cancer therapy
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