In a report published in the British Journal of Urology based on data from the phase III trial, authors conclude that dapoxetine is well-tolerated and improved measures associated with premature ejaculation, including reduction of personal distress, interpersonal difficulty and improvement in the satisfaction with the sexual intercourse.
Dapoxetine is the only approved medication to treat premature ejaculation.
Originally known as LY 210448, it was being developed by Lilly as an antidepressant.
Eli Lilly sold the patent to Johnson & Johnson for $65 million dollars and future royalties in December 2003.
In 2004, dapoxetine was submitted to the FDA in the form of dapoxetine hydrochloride by the ALZA Corporation and its parent company, Johnson & Johnson, for the treatment of premature ejaculation with a New Drug Application (NDA).
However, the FDA issued a "not approvable" letter for dapoxetine, requiring additional clinical study.
Two further clinical trials were completed in 2006, and approval is under review by the FDA.
Dapoxetine has been submitted for approval in the European Union and is being reviewed.
In 2009, dapoxetine received approval in Sweden, Finland, Austria, Portugal, Germany, Italy and Spain.
Approvals for dapoxetine are also anticipated in other European countries as well. In addition, filings for approval have been submitted in Canada, Australia, Mexico, Turkey and six other countries.
Priligy ® (marchio registrato) (dapoxetine hydrochloride) is the first oral medicine approved to treat premature ejaculation.
This sexual problem causes stress to millions of men worldwide, but until Priligy ® (marchio registrato), there was no way to treat the condition.
You can safely buy Priligy ® (marchio registrato) online to get relief from this condition and to enjoy more satisfying and prolonged sex with your partner.
Men taking Priligy ® (marchio registrato) dapoxetine hydrochloride have been able to increase their level of sexual performance by 200-300%.
Priligy ® (marchio registrato) (dapoxetine hydrochloride) is available in the dosage strengths of 30mg and 60mg.
Your doctor will probably recommend the 30mg dose first, to assess its effectiveness.
Your doctor may increase your Priligy ® (marchio registrato) dapoxetine dosage to 60mg if the effect of Priligy ® (marchio registrato) 30mg is not satisfactory, but is well tolerated by your body.
Priligy ® (marchio registrato) dapoxetine should be taken 1 to 3 hours before starting any sexual activity.
Priligy ® (marchio registrato) does have some side effects which tend to be mild to moderate in nature.
However, they do not affect everyone who takes the drug.
Priligy ® (marchio registrato) has a short half life, which works to significantly reduce the intensity of any side effects, making it a safe and efficient way to treat your condition.
Mild side effects you make experience whilst taking Priligy ® (marchio registrato) include nausea, dizziness, headaches, diarrhoea, stomach pains, bloating or sickness.
Some patients have reported feeling irritable, anxious, agitated or restless and numb, or have had difficulties achieving or maintaining an erection for a short period.
You may also sweat more than normal, experience constipation or wind, have problems sleeping, experience strange dreams or feel tired and sleepy.
Some men have also reported increased amounts of nasal congestion, a rise in blood pressure, difficulties concentrating, shaking or trembling, a decreased interest in sex, ringing in your ears, blurred vision, indigestion and a dry mouth.
These side effects are uncommon and affect less than 1 in 100 people.
A small percentage of men have reported changes in their mood - feeling overly excited or feeling paranoid, slow or irregular heartbeats, an increase in heart rate, feeling confused, disoriented or unable to think clearly, a loss of sex drive, problems reaching orgasm, feeling depressed, nervous or indifferent, feeling weak, sedated, lethargic or fatigued, hot, jittery, abnormal or drunk, experience vision problems or dilated pupils, low or high blood pressure, feeling itchy or experiencing cold sweats, spinning sensations, abnormal tastes or teeth grinding.
You should never take more than 1 Priligy ® (marchio registrato) dapoxetine dose in 24 hours.
You should never change your prescribed dose without consulting a doctor first.
It's advisable not to consume alcohol and take Priligy ® (marchio registrato), as this can work to further enhance alcohols effects such as feeling dizzy, sleepy and having slow reactions.
Consuming alcohol after taking Priligy ® (marchio registrato) may also cause fainting.
You have to consult your doctor before the beginning of any treatment program