Il Prof. Pierpaoli

Walter Pierpaoli non è uno stregone o un mago, ma un medico, un uomo curioso della natura e della biologia, che ha passato quasi 40 anni ben documentati  nell'allegra compagnia dei topolini, in attesa paziente che essi gli insegnassero come e perché invecchiamo e moriamo.

La sua principale caratteristica personale è la resistenza alle avversità e un'abilità molto radicata ad evitare le mode della scienza.

Egli ha chiaramente identificato ed interpretato l'espressione biologica del programma genetico dell'invecchiamento nella "rete di comunicazione pinealica" e cerca ora di fermare e anche di invertire il corso dell'invecchiamento.

Il suo sentiero solitario non è stato ancora seguito, forse fortunatamente, da molti. Così può lavorare ancora in pace.

La folla genera aggressività e confusione e molte motivazioni nella cura della salute non sono indirizzate alla prevenzione delle malattie ma, al contrario……al loro mantenimento.

Prof. Dr. Walter Pierpaoli,  M.D., Ph.D.

Il Prof. Walter Pierpaoli è nato nel 1934 a Milano e qui ha concluso tutti i suoi studi.

Si è laureato con pieni voti in Medicina e Chirurgia nel 1960. Dopo una specializzazione in Cardiologia ed un periodo come Assistente Ospedaliero e di attività pratica (Studio Medico), ha insegnato come Assistente presso l'Istituto di Patologia Generale dell'Università di Milano, conducendo ricerche di biofisica (effetto fotodinamico) e usufruendo di una borsa di studio dell'Atomic Energy Commission degli Stati Uniti.

E' poi entrato nel 1963 nel Consiglio Nazionale delle Ricerche (CNR) come Ricercatore a Contratto e quindi come Direttore di Laboratorio del "Centro per lo Studio della Patologia Cellulare".

In tale veste ha operato fino al 1969. Nel 1966 è entrato come "visiting scientist" all'Istituto di Ricerca Medica di Davos-Platz, Svizzera.

Sempre nel 1969 ha conseguito la Libera Docenza in Immunologia (corrispondente al Dottorato di Ricerca o Ph.D. negli altri Paesi).

Date le dimissioni dal CNR nel 1969 per incompatibilità ambientale, rimase all'Istituto di Davos fino alla fine del 1976, per complessivi dieci anni.

Dal 1977 al 1980 ha lavorato con un suo gruppo autonomo presso l'Istituto di Anatomia dell'Università di Zurigo e dal 1980, avvalendosi di una collaborazione con l'Istituto Choay di Parigi, ha costituito a Zurigo un Istituto di Ricerca e una Fondazione per la Ricerca Biomedica di Base  (ora INTERBION). 

Tale Istituto e Fondazione si sono trasferiti dal 1988 nel Ticino, ove si trovano attualmente in veste definitiva, dopo un tentativo di trasferimento ad Ancona (Italia) negli anni 1993 – 1996.

Attualmente (2007) il Prof. Pierpaoli è Presidente della Fondazione INTERBION e dirige la Ricerca appoggiandosi ai laboratori del ricostituito "Jean Choay  Institute for Neuroimmunomodulation" a Riva San Vitale, in Svizzera.

Il Prof. Pierpaoli ha pubblicato oltre 130 Lavori Scientifici sperimentali, quasi unicamente sulle migliori Riviste Scientifiche internazionali come "NATURE", (7 articoli),  "JOURNAL OF THE NATIONAL CANCER INSTITUTE - U.S.A.", "PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES - U.S.A.", e molti altri.

Egli organizza le notissime "Conferenze di Stromboli sul Cancro e l'Invecchiamento" che si sono svolte nel 1987, 1990, 1993 e 2005.

La Quinta Conferenza è prevista nel giugno 2008. I Volumi sulle Conferenze di Stromboli,  pubblicati dalla "NEW YORK ACADEMY OF SCIENCES" di New York, sono stati i più venduti nella storia della più gloriosa e antica Società Scientifica degli USA. 

Il Prof. Pierpaoli ha promosso per primo da molti anni gli studi medici interdisciplinari chiamati ora "Neuroimmunomodulazione", ai quali si dedicano ora migliaia di ricercatori.

Ha ideato, sulla base delle sue ricerche originali, interventi contro le malattie dell'invecchiamento e sta conducendo da molti anni negli Stati Uniti a Seattle, con un gruppo di  ricercatori presso il notissimo "Fred Hutchinson Cancer Research Center", ricerche iniziate nel 1978 e basate su un nuovo metodo di trapianti che permette di modificare il sistema immunitario e di evitare il rigetto degli organi.

Tale Progetto, protetto da Brevetti mondiali, è in una fase avanzatissima di sviluppo e si prevedono i primi internati clinici in patologie diffusissime, fra le quali il diabete e il cancro.

Le informazioni presenti in questa pagina potrebbero essere incomplete e/o non corrette.

La formulazione di melatonina del Dr. Pierpaoli.

PUBBLICAZIONI SCIENTIFICHE

1961

1. Pierpaoli, W. and Santamaria, L. Ulteriori indagini sull'evidenza di processi fotodinamici naturali nella retina di vitello. Atti della Società Italiana di Patologia, 7, 867, 1961.

1962

2. Santamaria, L. and Pierpaoli, W. Action of visible light and X-rays on isolated calf retina. Communication at the 2nd International Congress of Radiation Research. Harrogate, England, 1962, p. 235 (abstract).

1963

3. Pierpaoli, W. and Pace, G. Modificazioni elettrocardiografiche da effetto fotodinamico su cuore isolato di mammifero. Bollettino di Chimica Farmaceutica, 102, 20, 1963.

 4. Pace, G. and Pierpaoli, W. Photodynamic effect of dihydroquinidine on isolated hearts of mammals. Nature, 199, 915, 1963.

1964

5. Clerici, E., Pierpaoli, W. and Romussi, M. Rapporti tra tolleranza immunologica alla caseina ed amiloidosi sperimentale. Rendiconti della Classe di Scienze Fisiche, Matematiche e Naturali dell'Accademia Nazionale dei Lincei, s. VIII, 36, 315, 1964.

6. Pierpaoli, W. and Clerici, E. Immunological aspects of experimental amyloidosis. Experientia,20, 693, 1964.

1965

7. Pace, G. and Pierpaoli, W. Photodynamic effect of dihydroquinidine on the oxidative phosphorylation by mitochondria of mammal hearts. Radiation Research, 25, 309, 1965

8. Pierpaoli, W., Pace, G. and Grisler, R. Wirkung des Chinidins auf die oxydative Phosphorylierung und auf den K-Gehalt in den Mitochondrien des Herzmuskels. Experientia, 21, 410, 1965.

9. Pace, G., Pierpaoli, W. and Clerici, E. Glicolisi aerobia di tessuti normali sospesi in differenti "media" di incubazione. Atti della Società Italiana di Patologia, 9, 789, 1965.

10. Provini, L., Mocarelli, P., Pierpaoli, W. and Clerici, E. Relazioni fra sistema nervoso vegetativo e rigenerazione epatica. Atti della Società Italiana di Patologia 9, 789, 1965.

11. Clerici, E., Pierpaoli, W. and Romussi, M. Experimental amyloidosis in immunity. Pathologia et Microbiologia, 28, 806, 1965.

12. Clerici, E., Mocarelli, P., Pierpaoli, W. and Natale, N. Induzione dell'amiloidosi in conigli timectomizzati e/o appendicectomizzati alla nascita. Convegno sul Timo, Cernobbio, Como, Italy, 27 June 1965. Minerva Pediatrica.

13. Provini, L., Clerici, E., Pierpaoli, W. and Mocarelli, P. Proprietà immunologiche dell'amiloidosi estrattiva. Bollettino della Società Italiana di Biologia Sperimentale 41, fasc. 20 bis, 1965.

14.Clerici, E., Pierpaoli, W., Mocarelli, P. and Villa, M.L. Timectomia neonatale e amiloidosi sperimentale. Atti della Società Italiana di Patologia, 9, 667, 1965.

1966

15.Clerici, E., Mocarelli, P., Pierpaoli, W., Provini, L. and Villa, M.L. Induction of experimental amyloidosis in neonatally thymectomized mice. Clin. Exp. Immunol. 1, 425, 1966.
 
 
1967

16. Pierpaoli, W. Experimental amyloidosis and renal disease. Experientia, 23, 561, 1967.

17. Pierpaoli, W. and Blazkovec, A.A. Glomerulonefrite sperimentale ed amiloidosi da caseina nel ratto albino. Atti della Società Italiana di Patologia 10, 967, 1967.

18.Pace, G., Pierpaoli, W. and Clerici, E. Aerobic glycolysis of normal tissues suspended in thoracic duct lymph. Experientia, 23, 63, 1967.

19.Pierpaoli, W. Thymectomy and the prolongation of tolerance to bovine serum albumin in adult Rats. Nature 214, 802-803, 1967.

20.Pierpaoli, W. and Sorkin, E. Relationship between thymus and hypophysis. Nature 215, 834-837, 1967.

21. Pierpaoli, W. and Sorkin, E. Cellular modifications in the hypophysis of neonatally thymectomized mice. Brit. J. Exp. Path. 48, 627-631, 1967.

22. Pierpaoli, W. and Sorkin, E. Modificazioni cellulari ipofisarie nel topo dopo timectomia neonatale. Atti della Società Italiana di Patologia 10, 973, 1967.

1968

23. Pierpaoli, W. an Sorkin, E. Effect of gonadectomy on the peripheral lymphatic tissue of neonatally thymectomized mice. Brit. J. Exp. Path. 49, 288-293, 1968.

24. Pierpaoli, W. and Sorkin, E. Hormones and immunological capacity. I: Effect of heterologous anti-growth hormone (ASTH) antiserum on thymus and peripheral lymphatic tissue in mice. Induction of a wasting syndrome. J. Immunol. 101, 1036-1043, 1968.

1969

25.Pierpaoli, W. and Sorkin, E. Effect of growth hormone and anti-growth hormone serum on the lymphatic tissue and the immune response. Antibiotica et Chemotherapia 15, 122-134, (Edited by E. Sorkin). Karger Verlag, Basel, 1969.

26.Pierpaoli, W., Baroni, C., Fabris, N. and Sorkin, E. Hormones and immunological capacity. II. Reconstitution of antibody production in hormonally deficient mice by somatotropic hormone, thyrotropic hormone and thyroxine. Immunology 16, 217-230, 1969.

27.Pierpaoli, W. and Sorkin, E. A study on anti-pituitary serum. Immunology 16, 311-318, 1969.

28.Pierpaoli, W. and Sorkin, E. Relationship between developmental hormones, the thymus, and immunological capacity. In: Lymphatic tissue and germinal centers in immune response, pp397-401. (Edited by L. Fiore Donati and M.C. Hanna, Jr.). Plenum Press, New York, 1969.

1970

29. Fabris, N., Pierpaoli, W. and Sorkin, E. Hormones and the immune response. In: Developmental Aspects of Antibody Formation and Structure. Vol. I, pp 79-87 (Edited by J. Sterzl and J. Riha). Publishing House of the Czechoslovak Academy of Science, Prague, 1970.

30.Pierpaoli, W., Fabris, N. and Sorkin, E. Developmental hormones and immunological maturation. In: Hormones and the Immune Response, pp126-143. Ciba Foundation Study Group No. 36. (Edited by G.E.W. Wolstenholme and Julie Knight). Churchill, London, 1970.

1971

31.Pierpaoli, W., Fabris, N. and Sorkin, E. The effects of hormones on the development of the immune capacity. In: Cellular Interactions in the Immune Response, pp25-30. (Edited by S. Cohen, G. Cudkowicz and R.T. McCluskey). Karger, Basel, 1971.

32.Fabris, N., Pierpaoli, W. and Sorkin, E. Hormones and the immunological capacity. III. The immunodeficiency disease of the hypopituitary Snell-Bagg dwarf mouse.Clin. Exp. Immunol. 9, 209-225, 1971.

33.Fabris, N., Pierpaoli, W. and Sorkin, E. Hormones and the immunological capacity. IV. Restorative effects of developmental hormones or lymphocytes on the immunodeficiency syndrome of the dwarf mouse. Clin. Exp. Immunol. 9, 227-240, 1971.

34.Bianchi, E., Pierpaoli, W. and Sorkin, E. Cytological changes in the mouse anterior pituitary after neonatal thymectomy: a light and electron microscopical study. J. Endocrin. 51, 1-6, 1971.

35.Pierpaoli, W., Bianchi, E. and Sorkin, E. Hormones and the immunological capacity. V. Modification of growth hormone producing cells in the adenohypophysis of neonatally thymectomized germ-free mice: an electron microscopical study. Clin. Exp. Immunol.9, 889-901, 1971.

1972

36.Sorkin, E., Pierpaoli, W., Fabris, N. and Bianchi, E. Relation of growth hormone to thymus and the immune response. Proceedings of the Second International Symposium on Growth Hormone,Milano, 1971. Excerpta Medica Foundation, Amsterdam (Edited by A. Pecile and E.E. Müller),244, 132-142, 1972.

37.Pierpaoli, W. and Sorkin, E. Immunological blockade of the adenohypophysis and its possible application to prophylaxis and therapy of neoplasia. Experientia, 28, 336-339, 1972.

38.Pierpaoli, W. and Sorkin, E. Specificity and properties of antiadenohypophysis serum. I. Mode of preparation, titration and effects of neonatal injection into rats. Clin. Exp. Immunol. 11, 427-439, 1972.

39.Pierpaoli, W. and Sorkin, E. Inhibition of growth of methylcholanthrene (MC)-induced mammary carcinoma in rats by anti-adenohypophysis (anti-AH) serum. Nature New Biology 238, 58-59, 1972.

40.Pierpaoli, W. and Sorkin, E. Alterations of adrenal cortex and thyroid in mice with congenital absence of the thymus. Nature New Biology 238, 282-285, 1972.

41.Pierpaoli, W. and Sorkin, E. A thymus dependent function of the adrenal cortex and its relation to immunity. Experientia 28, 1385-1389, 1972.

42.Pierpaoli, W. and Sorkin, E. Hormones, thymus and lymphocyte functions. Experientia 28, 1385-1389, 1972.

43.Fabris, N., Pierpaoli, W. and Sorkin, E. Lymphocytes, hormones and aging. Nature 240, 557-559,1972.
 
 
1973

44.Pierpaoli, W. and Sorkin, E. Influence of thymus on the development of endocrine and immune functions in ontogeny. In: Microenvironmental Aspects of Immunity (Edited by B.D. Jankovic and K. Isakovic), pp651-654. Plenus Press, new York, 1973.

1974

45.Pierpaoli, W., Haran-Ghera, N., Bianchi, E., Müller, J., Meshorer, A. and Bree, M. Endocrine disorders as a contributoty factor to neoplasia in the SJL/J strain of mice. J. Natl. Cancer Inst. 53, 731-744, 1974.

1975

46. Pierpaoli, W. and Sorkin, E. Immunological blockade of the hypophysis. In: Host defence in Breast Cancer. (Edied by B.A. Stoll), pp 172-190. Heinemann, London, 1975.

47.Pierpaoli, W. and Haran-Ghera, N. Prevention of induced leukemia in mice by immunological blockade of adenohypophysis. Nature 254, 334-335, 1975.

48. Pierpaoli, W. and Besedovsky, H.O. Role of the thymus in programming of neuroendocrine functions. Clin. Exp. Immunol. 20, 323-338, 1975.

49. Pierpaoli, W. and Besedovsky, H.O. Failure of "thymus factor" to restore transplantation immunity in athymic mice. Brit. J. Exp. Path. 56, 180-182, 1975.

50. Pierpaoli, W. Inability of thymus cells from newborn donors to restore transplantation immuniy in athymic mice. Immunology 29, 465-468, 1975.

1976

51. Pierpaoli, W., Kopp, H.G. and Bianchi, E. Interdependence of thymic and neuroendocrine functions in ontogeny. Clin. Exp. Immunol. 24, 501-506, 1976.

1977

52. Pierpaoli, W., Haran-Ghera, N. and Kopp, H.G. Role of the host endocrine status in murine leukaemogenesis. Brit. J. Cancer 35, 621-629, 1977.

53. Pierpaoli, W., Kopp, H.G., Müller, J. And Keller, M. Interdependence between neuroendocrine programming and the generation of immune recognition in ontogeny. Cell. Immunol. 29, 16-27, 1977.

54. Pierpaoli, W., Hämmerli, M., Sorkin, E., Hurni, H. Role of thymus and hypothalamus in ageing. V. European Symposium on Basic Research in Gerontology, pp 141-150. Weimar, Verlag Dr. Med. D. Straube, Erlangen, DRG, 1977.

55. Pierpaoli, W. and Maestroni, G. Pharmacological control of the immune response by blockade of the early hormonal changes following antigen injection. Cell. Immunol. 31, 355-363, 1977.

56. Pierpaoli, W. Changes of the hormonal status in young mice by restricted caloric diet. Experientia 33, 1612-1613, 1977.

1978

57. Pierpaoli, W. and Maestroni, G. Pharmacological control of the hormonally modulated immune response. II. Blockade of antibody production by a combination of drugs acting on neuroendocrine functions. Its prevention by gonadotropins and corticotrophin. Immunology 34, 419-430, 1978.

58. Pierpaoli, W. and Maestroni, G. Pharmacological control of the hormonally modulated immune response. III. Prolongation of allogeneic skin graft rejection and prevention of runt disease by a combination of drugs acting on neuroendocrine functions. J. Immunol. 120, 1600-1603, 1978.

59. Pierpaoli, W. and Maestroni, G. Drug-induced chimerism and prevention of graft-versus-host disease in lethally irradiated mice transplanted with rat bone marrow.Transplantation 26, 456- 458, 1978.

1979

60. Pierpaoli, W. and Maestroni, G. A new pre-irradiation conditioning regimen which protects against radiation injury and facilitates engraftment of xenogeneic bone marrow. Scand. J. Haematol. 22, 165-172, 1979.

61. Pierpaoli, W. and Maestroni, G. Prevention of graft-versus-host disease and induction of chimerism in lethally irradiated mice reconstituted with rat bone marrow. J. Clin. and Lab. Immunol. 2, 125-132, 1979.

spaziatore
spaziatore
1980

62. Pierpaoli, W. and Maestroni, G. Facilitation of enduring engraftment of homologous bone marrow and avoidance of secondary disease in mice. Cell. Illunol. 52, 62-72, 1980.

63. Pierpaoli, W. and Maestroni, G. Induction of enduring allogeneic bone marrow chimerism in rabbits via soluble marrow-derived components. Immunol. Let. 1, 255-258, 1980.

64. Maestroni, G. and Pierpaoli, W. Factor(s) elaborated by bone marrow that promote persistentengraftment of xenogeneic and semiallogeneic marrow. J. Clin. Lab. Immunol. 4, 189-193, 1980.

1981

65. Pierpaoli, W., Maestroni, G. and Sache, E. Enduring allogeneic marrow engraftment via nonspecific bone marrow-derived regulating factors (MRF). Cell. Immunol. 57, 219-228, 1981.

66. Maestroni, G. and Pierpaoli, W. Pharmacological control of the hormonally mediated immune response. In: Psychoneuroimmunology, pp 405-428 (Edited by R. Ader), Academic Press, New York, 1981.

67. Pierpaoli, W. Integrated phylogenetic and ontogenetic evolution of neuroendocrine and identity-defence, immune functions. In: Psychoneuroimmunology, pp 575-606 (Edited by R. Ader), Academic Press, New York, 1981.

1982

68. Maestroni, G., Pierpaoli, W. and Zinkernagel, R.M. Immunoreactivity of long-lived H-2 incompatible irradiation chimeras (H-2d® H-2b). Immunology 46, 253-260, 1982.

69. Pierpaoli, W. and Meshorer, A. Host endocrine status mediates oncogenesis: leukemia virus-induced carcinomas and reticulum cell sarcomas in acyclic or normal mice. Europ. J. Cancer, 18, 1181-1186, 1982.

1983

70. Pierpaoli, W. and Maestroni, G. Marrow regulating factors (MRF) and radiation chimeras: a model for bone marrow-directed. In: Immunoregulation, pp133-140. (Edited by N. Fabris, E. Garaci, J. Hadden and N.A. Mitchison). Plenum Press, New York, 1983.

71. Maestroni, G. and Pierpaoli, W. Rejection of P2 skin grafts by long lived H-2 incompatible GVHD-free bone marrow chimeras (P1® P2). Transplantation 36, 461-463, 1983.

72. Maestroni, G. Pierpaoli, W. and Zinkernagel, R.M. Allogeneic H-2d® H-2b irradiation bone marrow chimeras: a) Failure to transfer chimerism adoptively and b) Immune reactivity of immunocompetent lymphocytes adoptively transferred to chimeras. Immunobiology 164, 417-429, 1983.

73. Pierpaoli, W. and Maestroni, G. Dominance and persistence of donor marrow in long-lived allogeneic radiation chimeras obtained with unmanipulated bone marrow. Immunol. Let. 6, 197-202, 1983.

74. Cuk, M., Radosevic-Stasic, B., Pierpaoli, W. and Rukavina, D. Bone marrow-liver-spleen axis in the regulation of morphostasis. Period. Biol. 85, 23-24, 1983.

1984

75. Pierpaoli, W. and Maestroni, G. Marrow regulating factors (MRF) and allogeneic bone marrow transplantation: a model for morphostasis and immunity. In: Human's Physiology (Russian), 10, 234-241, 1984.

76. Pierpaoli, W. and Maestroni, G. Enduring allogeneic and xenogeneic hemopoietic engraftment via marrow-derived regulating factors (MRF). In: Tolerance in Bone Marrow and Organ Transplantation (Edited by S. Slavin) pp 403-414. Elsevier, Amsterdam, 1984.

77. Pierpaoli, W. The bone marrow, our autonomous morphostatic "brain". In: Breakdown in Human Adaptation to Stress. Towards a Multidisciplinary Approach. Vol.II, pp 713-721. Martinus Nijhoff Publishers, The Hague, 1984.

1985

78. Pierpaoli, W. Immunoregulatory and morphostatic function of bone marrow-derived factors. In: Neural Modulation of Immunity (Edited by R. Guillemin, M. Cohn and T. Melnechuk) pp 205-220. Raven Press, New York, 1985.

79. Pierpaoli, W. Growth of transplantable melanoma and leukemia and prevention of virus-induced leukemia in long-lived radiation chimeras constructed with unmanipulated bone marrow. Clin Exp. Immunol. 59, 210-216, 1985.

80. Pierpaoli, W., Kellerhals, R., Buehler, A. and Sache, E. Experimental manipulations and marrow- derived factors which affect the outcome of bone marrow transplantation across the H-2 barrier in lethally irradiated mice. J. Clin. Lab Immunol. 16, 115-124, 1985.

81. Pierpaoli, W. Modulation of immunity by drugs. Immunology Today 6, 288, 1985.

1986

82. Maestroni, G., Conti, A. and Pierpaoli, W. Role of the pineal gland in immunity. I. The cyclic circadian synthesis and release of the pineal neurohormone melatonin regulates the antibody response in vivo and antagonizes the immunosuppressive effect of corticosterone. J. Neuroimmunol. 13, 19-30, 1986.

83. Maestroni, G., Conti, A. and Pierpaoli, W. Melatonin regulates immunity via an opiatergic mechanism. Clin. Neuropharmacol. 9, Suppl. 4, 479-481, 1986.

1987

84. Maestroni, G., Conti, A. and Pierpaoli, W. The pineal gland and the circadian, opiatergic, immunoregulatory role of melatonin. Ann. N.Y. Acad. Sci. 496, 67-77, 1987.

85. Pierpaoli, W., Balakrishnan, J., Sache, E., Choay, J. and Maestroni, G. Neuroendocrine and bone marrow factors for control of marrow transplantation and tissue regeneration. Ann. N.Y. Acad. Sci. 496, 27-38, 1987.

86. Pierpaoli, W. Neuroimmunomodulation: an approach to therapy of neurological diseases. In: Clinical Neuroimmunology (Edited by Aarli, J.A., Behan, W.M.H. and Behan, P.O.) pp. 500-505. Blackwell, Oxford, 1987.

87. Regelson, W. and Pierpaoli, W. Melatonin, a rediscovered anti-tumor hormone? Its relation tosurface receptors; sex steroid metabolism; immunologic response, and chronobiologic factors intumor growth and therapy. Cancer Invest. 5, 379-385, 1987.

88. Pierpaoli, W. and Maestroni, G. Melatonin: a principal neuroimmunoregulatory and anti-stress hormone: its anti-aging effects. Immunol. Let. 16, 355-362, 1987

89. Maestroni, G., Conti, A. and Pierpaoli, W. Role of the pineal gland in immunity. II. Melatonin enhances the antibody response via an opiatergic mechanism. Clin. Exp. Immunol. 68, 384-391, 1987.

90. Pierpaoli, W., Balakrishnan, J., Yi, C.X., Maestroni, G, Conti, A., Sache, E. and Choay, J. Linkage of pineal melatonin, neuropeptides and bone marrow inhibitors for the control of normal and neoplastic growth. 15th Int. Congress of Chemotherapy, Istanbul, Vol. 3. Progress in Chemother. Anticancer Section, 57-59, 1987.

1988

91. Pierpaoli, W. and Maestroni, G. Neuroimmunomodulation: some recent views and findings. Int. J. Neurosci. 39, 165-175, 1988.

92. Maestroni, G., Conti, A. and Pierpaoli, W. Role of the pineal gland in immunity. III. Melatonin antagonizes the immunosuppressive effect of acute stress via an opiatergic mechanism. Immunology 63, 465-469, 1988.

93. Maestroni, G., Conti, A. and Pierpaoli, W. Pineal melatonin, its fundamental immunoregulatory role in aging and cancer. Ann. N.Y. Acad. Sci. 521, 140-148, 1988.

94. Pierpaoli, W., Balakrishnan, J., Maestroni, G., Sache, E. and Choay, J. Bone marrow: a "morphostatic brain" for control of normal and neoplastic growth. Experimental evidence. Ann. N.Y. Acad. Sci. 521, 300-311, 1988.

1989

95. Maestroni, G., Conti, A. and Pierpaoli, W. Melatonin, stress and the immune system. In: Pineal Research Reviews,Vol. 7 (Edited by Reiter R.J.) pp 203-226. Alan R. Liss, New York, 1989.

1990

96. Pierpaoli, W. and Yi, C.X. The pineal gland and melatonin: the aging clock? A concept and experimental evidence. In: Stress and the Aging Brain. Aging Series, Vol. 37. (Edited by Nappi, G., Martignoni, E., Genazzani, A.R. and Petraglia, F.) pp 171-175. Raven Press, New York, 1990.

97. Pierpaoli, W. and Yi, C.X. The involvement of pineal gland and melatonin in immunity and aging. I. Thymus-mediated, immunoreconstituting and antiviral activity of thyrotropin releasing hormone (TRH). J. Neuroimmunol. 27, 99-109, 1990.

98.Pierpaoli, W.,Yi, C.X. and Dall'Ara, A. Aging-postponing effects of circadian melatonin: experimental evidence, significance and possible mechanisms. Int. J. Neurosci. 51, 339-340, 1990.

1991

99. Pierpaoli, W., Dall'Ara, A., Pedrinis, E. and Regelson, W. The pineal control of aging: the effects of melatonin and pineal grafting on the survival of older mice. Ann. N.Y. Acad. Sci. 621, 291-313, 1991.

100. Pierpaoli, W., Dall'Ara, A., Yi, C.X., Neri, P., Santucci, A. and Choay, J. Iron carrier proteins facilitate engraftment of allogeneic bone marrow and enduring hemopoietic chimerism in the lethally irradiated host. Cell. Immunol. 134, 225-234, 1991.

101. Lesnikov, V.A., Isaeva, E.N., Korneva, E.A. and Pierpaoli, W. Melatonin reconstitutes the decreased CFU-S content in the bone marrow of hypothalamus-lesioned mice. In: Role of Melatonin and Pineal Peptides in Neuroimmunomodulation. (Edited by Fraschini, F. and Reiter, R.) pp 225-231. Plenum Press, New York, 1991.

102. Pierpaoli, W. The pineal gland: a circadian or seasonal aging clock? Aging 3, 99-101, 1991.
 
 
1992

103. Lesnikov, V.A., Korneva, E.A., Dall'Ara, A. and Pierpaoli, W. The involvement of pineal gland and melatonin in immunity and aging. II. Thyrotropin releasing hormone and melatonin forestall involution and promote reconstitution of the thymus in anterior hypothalamic area (AHA)-lesioned mice. Int. J. Neurosci. 62, 141-153, 1992.

104. Pierpaoli, W. Effect of human transferrin on engraftment of allogeneic bone marrow in different strains of lethally irradiated mice. Nat. Immun. and Cell Growth Regul. 11, 356-365, 1992.

1993

105. Pierpaoli, W. Pineal grafting and melatonin induce immunocompetence in nude (athymic) mice. Int. J. Neurosci. 68, 123-131, 1993.

1994

106. Pierpaoli, W. and Regelson, W. The pineal control of aging. The effect of melatonin and pineal grafting on aging mice. Proc. Natl. Acad. Sci. USA, 91, 787-791, 1994.

107. Pierpaoli, W. The pineal aging clock. Evidence, models and an approach to aging-delaying strategies. In: Aging, Immunity and Infections (Edited by Powers, D.C., Morley, J.E. and Coe, R.M.) pp. 166-175. Springer Publishing Company, New York, 1994.

108. Pierpaoli, W. and Lesnikov, V.A. The pineal aging clock. Evidence, models, mechanisms, interventions. Ann. N.Y. Acad. Sci. 719, 461-473, 1994.

109. Lesnikov, V.A. and Pierpaoli, W. Pineal cross-transplantation (old« young) as evidence for an endogenous "aging clock". Ann. N.Y. Acad. Sci. 719, 456-460, 1994.

110. Mocchegiani, E., Bulian, D., Santarelli, L., Tibaldi, A., Pierpaoli, W. and Fabris, N. The zinc-melatonin interrelationship. Ann. N.Y. Acad. Sci. 719, 298-307, 1994.

111. Viticchi, C., Bulian, D., Pierpaoli, W. and Piantanelli, L. Brain a and b-adrenoceptors are differently modulated by pineal graft in aging mice. Ann. N.Y. Acad. Sci. 719, 448-453, 1994.

112. Mocchegiani, E., Bulian, D., Santarelli, L., Tibaldi, A., Muzzioli, M., Pierpaoli, W. and Fabris, N. The immuno-reconstituting effect of melatonin or pineal grafting and its relation to zinc pool in aging mice. J. Neuroimmunol. 53, 189-201, 1994.

113.Pierpaoli, W. The pineal gland as ontogenetic scanner of reproduction, immunity and aging. Ann. N.Y. Acad. Sci. 741, 46-49, 1994.

1995

114.Lissoni, P., Arosio, V., Mocchegiani, E., Fabris, N., Barni, S., Pierpaoli, W. and Tancini, G. Zinc levels in serum during subcutaneous interleukin-2 immunotherapy of cancer. Int. J. Biol. Markers 10, 124-125, 1995.

1996

115.Deeg, H.J., Pierpaoli, W., Arrighi, S., Seidel, K., Graham, T., Huss, R. Yu, C., Myerson, D., Schuening, F. and Storb, R. Facilitation of DLA-incompatible marrow grafts by donor-derived transferrin? Transplant Immunol. 4, 113-116, 1996.

116.Pierpaoli, W., Lesnikov, V.A., Lesnikova, M.P., Arrighi, S. and Bardotti, A. Specific xenogeneic (human) tolerance in immunosuppressed mice by combined donor-derived human transferrin and antigens. Transpl. Proc. 28, 711-712, 1996.

117.Pierpaoli, W., Lesnikov, V.A., Lesnikova, M.P. and Arrighi, S. Donor-derived plasma transferrin facilitates the engraftment of xenogeneic (rat) bone marrow in irradiated mice. Bone Marrow Transplantation 18, 203-207, 1996.

118.Pierpaoli, W., Lesnikov, V.A., Lesnikova, M.P., Arrighi, S. and Bardotti, A. Unresponsiveness to human leukocytes in immunosuppressed mice by combined donor-derived human transferrin and antigens. Transplant Immunol. 4, 301-308, 1996.

119.Mocchegiani, E., Bulian, D., Santarelli, L., Tibaldi, A. Muzzioli, M., Lesnikov, V.A., Pierpaoli, W. and Fabris, N. The zinc pool is involved in the immunoreconstituting effect of melatonin in pinealectomized mice. J. Pharm. and Exp. Therap. 277, 1200-1208, 1996.

120.Pierpaoli, W. Melatonin, the pineal gland and aging: a planetary and biological reality. In: The Science of Anti-Aging Medicine (Edited by Klatz, R. and Goldman, R.) pp. 107-114 .American Academy of Anti-Aging Medicine, Colorado Springs, 1996.

1997

121.Pierpaoli, W. and Lesnikov, V.A. Theoretical considerations on the nature of the pineal "aging clock". Gerontology 43, 20-25, 1997.

122.Pierpaoli, W., Bulian, D., Dall'Ara, A., Marchetti, B., Gallo, F., Morale, M.C., Tirolo, C. and Testa, N. Circadian melatonin and young-to-old pineal grafting postpone aging and maintain juvenile conditions of reproductive functions in mice and rats. Exp. Gerontol. 32, 587-602, 1997.

123.Pierpaoli, W. La melatonina, la pineale e l'invecchiamento: evidenza sperimentale di una nuova realtà biologica. Melatonina. Dalla Ricerca agli Interventi, pp. 145-152. Euromeeting .Edizioni, Torino, 1997.

124.Pierpaoli, W. and Lesnikov, V.A. Pineal control of stress, di-stress and aging: the melatonin evidence. Developmental Brain Dysfunction,  10, 528-537, 1997.

1998

125. Pierpaoli, W. Neuroimmunomodulation of aging: a programme in the pineal gland. Ann. N.Y. Acad. Sci. 840, 491-497, 1998.

126. Pierpaoli, W. Overcoming the histocompatibility barrier. Transferrins as carriers and modulators of immunogenic identity. Cell Transpl. 7, 541-548, 1998.

1999

127. Pierpaoli, W., Bulian D., Bulian G., and Kistler, G. Thyrotropin releasing hormone (THR) accelerates and enhances the aging-postponing effects of melatonin. J. Anti-Aging Med:2, 343-348,1999.

2000

128. Pierpaoli W. and Bulian, D. Transferrin treatment corrects aging-related immunologic and hormonal decay in old mice. Exp. Gerontol. 35, 401-408,  2000. 

129. Bulian, D. and Pierpaoli, W. The pineal control of cancer. I. Pinealectomy corrects congenital hormonal dysfunctions and prolongs life in cancer-prone C3H/He mice. J. Neuroimmunol. 108, 131-135, 2000.

130. Lesnikova, M., Lesnikov, V., Arrighi, S., Kistler, G., Pierpaoli, W. And Deeg, H.J. Upregulation of interleukin-10 and inhibition of alloantigen responses b transferrin and transferrin-derived glycans. J. Hematol.& Stem Cell Res. 9,381-392, 2000.

2001 

131. Pierpaoli, W and Bulian, D. The Pineal Aging and Death  Programme. I. Grafting of old pineals in young mice accelerates their aging. J. Anti-Aging Med. 4, 31-37, 2001.

132. Bellipanni, G., Bianchi, P., Pierpaoli, W., Bulian, D. and  Ilyia, E. Effects of melatonin in perimenopausal and menopausal women: a randomized and placebo-controlled study. Exp. Gerontol., 36, 297-310, 2001.  

2002

133. Lesnikov, V, Lesnikova, M., Shulman, H.M., Arrighi, S., Pierpaoli, W. And Deeg, H.J. In vivo cytoprotective and immunomodulatory effects of transferring. Submitted as "Camera Ready" to Global Research Network (India), 4/2002, revised on 07.30.2002. 

2003

134. Lesnikov, V.A., Lesnikova, M.P., Shulman, H.M., Wilson, H.-M., Hockenberry, D.M., Kocher, M., Pierpaoli, W. and Deeg, H.J. Prevention of Fas-mediated hepatic failure by Transferrin.  Laboratory Inv. , 2003,

2005

135. Pierpaoli, W. The rotational origin and state of the whole. Its relation to growth, fertility, aging, death, and diseases. Ann. N.Y. Acad. Sci. 1057, 1-15, 2005.

136. Pierpaoli, W.  Neurodegenerative diseases: a common etiology and a common therapy. Ann. N.Y. Acad. Sci., 1057, 319-326, 2005.

137. Pierpaoli, W., Bulian, D.  The pineal aging and death program. II. Life prolongation in pre-aging pinealectomized mice. Ann. N.Y. Acad. Sci., 1057, 133-144, 2005.

138. Yi, C., Pan, X., Yan, H., Guo, M. and Pierpaoli, W. Effects of melatonin in age-related macula degeneration. Ann. N.Y. Acad. Sci., 1057, 384-392, 2005.
 
 

Bibliografia degli studi scientifici del Prof. Pierpaoli su relazione tra melatonina e cancro

Pace,G.,Pierpaoli,W.e Clerici, E.Aerobic glycolysis of normal tissues suspended in thoracic  duct lymph. Experientia 23, 63, 1967.
Pierpaoli, W. e  Sorkin, E.  Relationship between thymus and hypophysis. Nature 215, 834, 1967.
Pierpaoli, W. and Sorkin, E. Effect of gonadectomy on the peripheral lymphatic tissue of neonatally     thymectomized mice. Brit. J. exp. Path. 49, 288, 1968.
Pierpaoli, W. and Sorkin, E. Hormones and immunological capacity. I. Effect of heterologous anti-growth hormone (ASTH) antiserum on thymus and peripheral lymphatic tissue in mice. Induction of a wasting syndrome. J. Immunol. 101, 1036, 1968.
Pierpaoli, W. and Sorkin, E. A study on anti-pituitary serum. Immunology 16, 311, 1969
Pierpaoli, W., Fabris, N. and Sorkin, E. Developmental hormones and immunological maturation. In: Hormones and the Immune Response, Ciba Foundation Study Group No. 36. G.E.W.Wolstenholme and Julie Knight, editori. Churchill, London, pp 126-143, 1970.
Pierpaoli, W. and Sorkin, E. Immunological blockade of the adenohypophysis and its possible application to prophylaxis and therapy of neoplasia. Experientia 28, 336, 1972.
Pierpaoli, W. and Sorkin, E. Specificity and properties of anti-adenohypophysis serum. Mode of preparation, titration and effects of neonatal injection into rats. Clin. exp. Immunol. 11, 427, 1972
Pierpaoli, W. and Sorkin, E. Inhibition of growth of methylcholanthrene (MC)-induced mammary      carcinoma by anti-adenohypophysis (anti-AH) serum. Nature New Biology 238, 58, 1972.
Pierpaoli, W. and Sorkin, E. Alterations of adrenal cortex and thyroid in mice with congenital      absence of the thymus. Nature New Biology 238, 282, 1972.
Fabris, N., Pierpaoli, W. and Sorkin, E. Lymphocytes, hormones and aging. Nature 240, 557, 1972.
Pierpaoli, W., Haran-Ghera, N., Bianchi, E., Mueller, J., Meshorer, A. and Bree, M. Endocrine   disorders as a contributory factor to neoplasia in the SJL/J strain of mice. J. Natl. Cancer Inst.     53, 731, 1974.
Pierpaoli, W. and Haran-Ghera, N. Prevention of induced leukemia in mice by immunological     inhibition of adenohypophysis. Nature 254, 334, 1975.
Pierpaoli, W. and Besedovsky, H.O. Role of the thymus in programming of neuroendocrine      functions. Clin. Exp. Immunol. 20, 323, 1975.
Pierpaoli, W., Haran-Ghera, N. and Kopp, H.G. Role of the host endocrine status in murine      leukemogenesis. Brit. J. Cancer 35, 621, 1977.
Pierpaoli, W. Changes of the hormonal status in young mice by restricted caloric diet. Relation to    lifespan extension.Preliminary results. Experientia 33, 1612, 1977.
Pierpaoli, W. and Maestroni, G. Drug-induced chimerism and prevention of graft versus-host     disease in lethally irradiated mice transplanted with rat bone marrow. Transplantation 26, 456, 1978.
Pierpaoli, W. and Maestroni, G.  and Sache, E. Enduring allogeneic marrow engraftment via non-specific bone marrow-derived regulating factor (MRF).Cell. Immunol. 57, 219, 1981.
Pierpaoli, W. and Meshorer, A. Host endocrine status mediates oncogenesis: leukemia  virus-     induced carcinomas and reticulum cell sarcomas in acyclic or normal mice. Europ. J. Cancer 18,     1181, 1982.
Pierpaoli, W. and Maestroni, G. Dominance and persistence of donor marrow in long-lived      allogeneic radiation chimeras obtained with unmanipulated bone marrow. Immunol Let.6,197, 1983.
Pierpaoli, W. Growth of transplantable melanoma and leukemia and prevention of virus-induced     leukemia in long-lived radiation chimeras constructed with unmanipulated bone marrow.     Clin. and Exp. Immunol. 59, 210, 1985.
Pierpaoli, W. Neuroimmunomodulation: an approach to the therapy of neurological diseases. In:Clinical Neuroimmunology, J.A. Aarli, W.M.H. Behan and P.O. Behan, editori.  Blackwell,     Oxford, pp 500-505, 1987
.Regelson, W. and Pierpaoli, W. Melatonin: a rediscovered anti-tumor hormone? Its relation to surface receptors; sex steroid metabolism; immunological response and chronobiologic factors in tumor growth and therapy. Cancer Investigations 5, 379, 1987.
Pierpaoli, W. and Maestroni, G. Melatonin: a principal neuroimmunoregulatory and anti-stress hormone: its anti-aging effects. Immunol. Let. 16, 355, 1987.
Pierpaoli, W., Balakrishnan, J. Maestroni, G., Sache, E. and Choay, J.  Bone marrow: a     "morphostatic brain" for control of normal and neoplastic growth. Experimental evidence.In:Neuroimmunomodulation: Interventions in Aging and Cancer. Ann. N.Y. Acad. Sci.521, 300, 1988
 (First Stromboli Conference on Aging and Cancer). Pierpaoli, W., Yi, C.X. and Dall'Ara, A. Aging-postponing effects of circadian melatonin:experimental evidence, significance and possible mechanisms. Int. J. Neurosci. 51, 339, 1990.
Pierpaoli, W. The pineal gland: a circadian or seasonal aging clock? Aging 3, 99, 1991.
Pierpaoli, W. and Regelson, W. The pineal control of aging. The effect of melatonin and pineal grafting on aging mice. Proc. Natl. Acad. Sci. USA, 91, 787, 1994.
Mocchegiani, E., Bulian, D., Santarelli, L., Tibaldi, A., Muzzioli, M. Pierpaoli, W. and Fabris, N.The immuno-reconstituting effect of melatonin or pineal grafting and its relation to zinc pool in     aging mice. J. Neuroimmunol. 53, 189, 1994.
Pierpaoli, W. The pineal gland as ontogenetic scanner of reproduction, immunity and aging.      In: Neuroimmunomodulation; The State of the Art. Ann. N.Y. Acad. Sci. 741, 46, 1994.
Deeg, H.J., Pierpaoli, W., Arrighi, S., Seidel, K., Graham, T., Huss, R., Yu, C., Myerson, D.,      Schuening, F. and Storb, R. Facilitation of DLA-incompatible marrow grafts by donor-specific serum transferrin? Transplant Immunol. 4, 113, 1996.
Pierpaoli, W., Lesnikov, V.A., Lesnikova, M.P., Arrighi, S. and Bardotti, A. Specific xenogeneic     (human) tolerance in immunosuppressed mice by combined donor-derived human transferrin     and antigens. Transpl. Proc. 28, 711, 1996.Pierpaoli, W., Lesnikov, V.A., Lesnikova, M.P. and Arrighi, S. Donor-derived plasma transferrin     facilitates the engraftment of xenogeneic (rat) bone marrow in irradiated mice. Bone Marrow     Transplantation 18, 203, 1996.
Pierpaoli, W., Lesnikov, V.A., Lesnikova, M.P., Arrighi, S. and Bardotti, A. Unresponsiveness     to human leukocytes in immunosuppressed mice by combined donor-derived human transferrin     and antigens. Transpl. Immunol. 4, 301, 1996.
Pierpaoli, W. and Lesnikov, V.A. Theoretical considerations on the nature of the pineal "aging  clock".Gerontology 43, 20, 1997
Bulian, D. and  Pierpaoli, W. The pineal gland and cancer. I. Pinealectomy corrects congenital    hormonal dysfunctions and prolongs life of cancer-prone C3H/He mice.  J. Neuroimmunol.    108, 131, 2000.