- PACIFEN (generic Baclofen)
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Treats pain of muscle spasms caused by multiple
sclerosis, spinal cord injuries, and other diseases. Belongs to a class of drugs called
muscle relaxants.
Baclofen is a highly effective antispastic with a spinal
site of attack. Baclofen depresses monosynaptic and polysynaptic reflex transmission in
the spinal cord by stimulating the GABA B-receptors, this stimulation in turn inhibiting
the release of the excitatory amino acids glutamate and aspartate.
Neuromuscular transmission is not affected by baclofen.
Baclofen exerts an antinociceptive effect. In neurological diseases associated with spasm
of the skeletal muscles, the clinical effects of baclofen take the form of a beneficial
action on reflex muscle contractions and marked relief from painful spasm, automatism, and
clonus. Baclofen improves the patient's mobility, facilitating management of daily
activities (including catheterisation) and physiotherapy. Prevention and healing of
decubitus ulcers, improvement in sleep patterns (due to elimination of painful muscle
spasms) and in bladder and sphincter function, have also been observed as indirect effects
of treatment with baclofen, leading to a better quality of life for the patients.
Baclofen stimulates gastric acid secretion.
- Indications
- Spasticity of the skeletal muscles in multiple sclerosis.
Spastic conditions occurring in spinal-cord diseases of infectious, degenerative,
traumatic, neoplastic, or unknown origin: e.g. spastic spinal paralysis, amyotrophic
lateral sclerosis, syringomyelia, transverse myelitis, traumatic paraplegia or
paraparesis, and compression of the spinal cord; muscle spasm of cerebral origin,
especially where due to infantile cerebral palsy, as well as following cerebrovascular
accidents or in the presence of neoplastic or degenerative brain disease.
You should not use this medicine if you have had an
allergic reaction to baclofen or if you have a history of seizures.
- Your doctor will tell you how much to take and how often.
- Take baclofen with food or milk to avoid upset stomach.
- Keep this medicine in the original tightly closed container,
away from moisture and direct light.
- Keep all medicine out of the reach of children.
If you miss a dose:
- Take the missed dose as soon as possible.
- If it is almost time for your next regular dose, wait until
then to take the medicine and skip the missed dose.
- You should not use two doses at the same time
Warnings
- Check with your doctor before taking baclofen if you have
stomach ulcers, kidney disease, a history of alcoholism, or other medical problems.
- This medicine may make you sleepy. Be careful while driving
a car or operating machinery.
- If you are pregnant or breastfeeding, talk to your doctor
before taking this medicine.
- Do not suddenly stop taking this medicine. You may need to
take smaller and smaller doses before you completely stop taking the medicine.
Side effects
Call your doctor right away if you have any of these side
effects:
- Rash or itching
- Chest pain or irregular heartbeat
- Bloody urine
- Tremors or seizures
- Slurred speech
If you have problems with these less serious side effects,
talk with your doctor:
- Loss of appetite or weight gain
- Frequent urination
- Upset stomach, nausea
- Diarrhea
- Headache
- Trouble sleeping or depressed mood
- Nervousness, dizziness, or drowsiness
- Weakness or tiredness
- Loss of sexual ability
If you have other side effects that you think are caused by
this medicine, tell your doctor.
