BIOHEAL / CP-SERUM / EMU-OIL / EXFOL CREAM / EXFOL SERUM / GENTLE CLEAN /  GLYCOLIC ACID / SALICYLIC ACID / PROTECT & RESTORE / TRI-REDUCTION
 
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->BioHeal 4oz US$ 29.95
->CpSerum 4oz US$ 33.95
->CpSerum+Exfol Serum US$ 51.95
->CpSerum Nail Renewal 0.5 oz US$ 24.95
->Emu Oil S 2 oz US$ 29.95
->Exfol Cream  2% salicylic acid 4oz US$21.95
->Exfol Serum  2% salicylic acid 4oz US$24.95
->Gentle Clean 8 oz US$ 14.95
->Herbal Hydrating Spray 8 fl. oz US$ 13.95, 6 items US$ 81
->Herbal Wash 8 fl. oz US$ 17.45, 6 items US$ 94.23
->Hydro-Lac Lotion 240ml, 8 fl. oz US$ 22.50, 6 items US$ 129.6
->Glycolic-8 4 oz US$ 39.95
->Iamin Idrating gel 85g 3 oz tube US$ 29.95, 6 x 3 oz tubes US$ 86.95
->Protect & Restore Skin Renewal Cream, Protect & Restore Skin Renewal Cream with High Retinol and oil of lavander, Protect & Restore Day Cover 4oz $33.95
->Protect & Restore Skin Renewal Cream + Glycolic-8 US$ 51.95
->Protect & Restore Suntanning Lotion 8 oz US$ 29.95
->TriReduction Basic, TriReduction with retinol 4oz US$ 39.95
->TriReduction Glycolic Exfoliator 14% 4oz US$ 24.95

Skin Biology's new and patented copper peptide technology is Dr. Pickart's most effective copper peptide system to date. These breakdown-resistant, improved copper peptides give a longer-acting and stronger skin regeneration and also can be used with hydroxy acids and Retin-A « (marchio registrato). The single peptides
(tripeptides or pentapeptides) used in many products are fragile, short-acting, and cannot be used with hydroxy acids. Extensive safety testing has proven Skin Biology's copper peptides to be nonallergenic and none irritating. Skin Biology's copper peptides have neither the allergenic sensitization problems of the bacterial produced copper peptides nor the biological inactivity ("colorless-copper") of copper complexes used by some irresponsible cosmetic companies.

Copper-peptides are used clinically for wound healing, increased skin healing after laser resurfacing and chemical peels, and for improving the success of hair transplantation. They help stimulate the skin's regenerative processes which repair the skin's protective outer barrier, increase new capillary formation (angiogenesis), increase the production of collagen and elastin which improve skin elasticity and firmness, and the increase the water-holding proteoglycans and glycosaminoglycans (GAGs) which hold moisture in the skin and are the only "true" moisturization of skin. They also activate the skin's system (called metalloproteinases) that removes damaged proteins such as scars and sun damage marks.

        Copper-peptides also improve the skin's anti-oxidant defenses by activating superoxide dismutase (SOD), a protein which de-toxifies free radicals and that is the body's primary anti-oxidant defense. Normally SOD lacks enough copper to be active and copper-peptides, by supplying nutritional copper to SOD, increase the activity of SOD.

        When creams containing copper-peptides are applied to the skin, only very small amounts of the copper-peptides penetrate into the skin. Copper-peptides have passed numerous safety tests. Scientific studies of copper-peptides have found that the amount of copper taken into the body from such copper-peptide creams is insignificant and does not raise total blood copper levels.  However, the microscopic amount of copper-peptide that does enter the skin's upper layer is sufficient to help stimulate skin regeneration.

Actions of Skin Regenerating Copper Peptides
Skin Repair Increases collagen synthesis producing firmer skin
Increases elastin synthesis producing more elastic skin
Increases synthesis of glycosaminoglycans and proteoglycans - the skin's water holding proteins
Stimulates new capillary formation for better cellular nutrition
Attracts macrophages to area of application - these are the skin repair cells
Removal of damaged protein and  Scar Reduction  Activates metalloproteinases that remove damaged protein
Suppresses production of TGF-beta, the scar producing factor
Anti-inflammatory Blocks release of oxidative iron from ferritin
Blocks damaging actions of Interleukin-1
Activates inert superoxide dismutase
Ingredient 

Biological Activity 

Effect on skin

Copper-peptides - 
Skin Biology has five US patents on this technology 
Increases activity of skin metalloproteinases 
(Copper-peptides are the only known activator of this activity) 
Removes skin proteins damaged by sunlight, oxygen radicals or 
sugar cross links - 
Removal allows deposition 
of new collagen and elastin
  Increases biosynthesis of new collagen and elastin  Tightens and firms skin 
  Increases production of proteoglycans and 
glycosaminoglycans 
Increases the skin's 
internal moisturization 
  Activates the skin's superoxide dismutase - 
Increases the skin's ability to de-toxify oxygen radicals in water areas of skin
Reduces damage from sun environmental pollutants 
  Repairs and tightens skin barrier  Skin become more resistant to irritants and allergens 
  Increases size of apocrine glands in skin May increase secretion of sexual pheromones for attraction
     
Retinol Increases wrinkle reduction  
  Increases skin oil  Eliminates dry skin problems 
  Decreases breakdown 
of undamaged skin proteins 
Excessive breakdown of skin protein occurs after age 45
     
Allantoin  Improves skin repair  Helps general skin repair
     
Squalane and Octyl Palmitate Rebuilds the protective acid mantle  Increases skin's first line of defense and protection
     
Mixed Tocopherols (vitamin E), 
mixed tocotrienols, 
Coenzyme Q10 
Inactivate damaging oxygen radicals
in fatty areas of skin 
Reduces damage from sun and environmental pollutants 
     
Titanium Dioxide - pure - P&R#7 Scatters and reflects sunlight and ultraviolet  A safe sunblocker 
Does not penetrate into skin
BIOHEAL, improve the health of "at-risk" skin and help prevent serious damage
Ingredients : purified water, squalane, octyl palmitate, glycerol stearate, PEG-100 stearate, cetyl alchol, copper peptides (hydrolyzed soy protein and copper chloride), stearic acid, allantoin, propylene glycol, camphor, mentol, diazolinydinyl urea, methylparaben, propylparaben, herbal fragrance, tocopheryl acetate.
BioHeal contains advanced Copper-Peptides that help your body to heal damaged skin that is dry, cracked, sore and itches. BioHeal's   Copper-Peptides also have anti-inflammatory properties to help alleviate rashes and skin irritations and are safer than cortisone and corticosteroids. BioHeal is designed to help maintain optimal skin health and to help prevent the development of more serious skin damage and infections in persons with skin that is "At-Risk". Studies at over 30 leading Universities and Medical Research Institutes by leading dermatologists and scientists have established the effectiveness on skin repair of Copper-Peptides invented by Dr. Loren Pickart.
BioHeal is a product that was developed to help speed skin repair in conditions that may lead to more serious skin damage, scarring, and infections. Persons who are at risk for more serious skin damage are those with diabetes, eczema, dry and cracking skin, skin allergies, psoriasis, immune-compromised status (HIV, immuno-suppressant therapy after transplants or after from cancer chemotherapy), the bedridden and persons in wheelchairs, and those with thermal burns and radiation burns.
BioHeal help enhance the skin's recovery of health after many types of skin irritations, skin damage and rashes. BioHeal contains our clinically-proven copper-peptides that form a repair-promoting protective film over the skin and also acts as a superoxide dismutase that can help de-toxify oxygen radicals that delay skin repair. BioHeal also rebuilds the skin's natural protective and anti-oxidant "acid mantle".
BioHeal is especially useful in maintaining healthy skin in persons "At-Risk" for skin damage. Persons with: Diabetes, eczema and dry, cracking skin, psoriasis, immune-compromised status (HIV, immuno-suppressant therapy), the bedridden and persons in wheelchairs, radiation-burned skin from cancer therapy, skin allergies such as nickel or poison ivy.
        The use of BioHeal often rapidly improves skin health in persons at risk for skin ulcers and bedsores and stops the further development of such sores. Prevention is much better than healing open skin wounds.
        BioHeal is also useful to help repair skin after hair removal methods (waxing, shaving, electrolysis) and rapidly reduces soreness in the skin. It also works well to help heal skin damage caused by nail polish removers which often produce a dry and cracking skin.
Skin Damaging Conditions and Effect of Copper-Peptide Creams

Condition Producing 
Skin Damage 

Defect Involved

Effect of Copper-Peptide Skin Repair Accelerators

Diabetes Inadequate protein synthesis  Strong stimulation of repair
HIV-AIDS condition Lack sufficient immune cells for skin repair Accelerators concentrate enough immune cells for adequate repair
Eczema  Degraded skin barrier Excellent results with creams and non-irritating cleanser
Contact dermatitis  Often degraded skin barrier allows passage of irritants Rebuilding skin barrier makes skin less sensitive to irritants 
Dry Skin - Sjorgren's syndrome  Damaged skin barrier causes excessive water loss  Excellent results in reliving dry skin. Skin barrier repaired and the skin's water-holding proteoglycans are increased
Thermal burns and radiation burns  "Zone-of-stasis" around injury blocks blood vessel growth and wound repair Accelerators stimulate blood vessel production and overcome zone-of-stasis barrier 
Post-chemotherapy  Lack of sufficient immune cells for skin repair Accelerators concentrate enough immune cells for adequate repair
Skin allergies  Excessive free radical production produces inflamed state  Copper activates superoxide dismutase defenses and reduces free radicals - skin repair then proceeds to completion
Psoriasis  Excessive production of certain types of skin cells leads to skin barrier damage  Skin barrier repair often stops itching and flaking - sometimes removes all problems psoriasis 
BioHeal is our skin cream specifically designed for repair "At-Risk" skin. However, our customers also use our Protect & Restore skin renewal creams for these purposes. The P&R creams have less copper-peptide,and no camphor or menthol.
        While BioHeal has the strongest effects on skin repair and has the most pain reduction, the P&R creams have more aesthetic appeal. P&R often works well. BioHeal has slightly more copper-peptide and sticks better to damaged skin. BioHeal also contains the non-drug pain reducers camphor and menthol.
BioHeal plus Emu Oil
Within the past year, a number of our customers have told us of good responses in alleviating or reducing eczema or psoriasis after the combined use of Emu Oil and BioHeal.  The fatty acid composition of human skin oil and emu oil are very similar. In both oils, mono-unsaturated oleic acid is the most prevalent, then palmitic acid, followed by the essential fatty acid, linoleic acid. This may be the reason for the positive actions of emu oil on human skin. (Zemtsov et al 1996)
A study by Lopez and colleagues (1999) found strong anti-inflammatory effects of topically applied emu oil after skin was exposed to the a very strong irritant - croton oil. By 12 hours after applying emu oil, there was significantly less edema and swelling  than controls not treated with the oil.
Politis and Dmytrowich (1998) found that if emu oil was applied immediately after a wounding injury, it delayed healing. However, if applied 2 days after injury, it them aided the healing process. So for skin repair, first use copper-peptides, then start using the emu oil.
Skin researchers at the University of Texas Medical School in Houston reported that emu oil at up to 100 % concentration in lotions to be nonallergenic, non-comedogenic, have low irritation potential, and to be bacteriostatic.
While scientific studies on emu oil are just beginning, emu oil has been traditionally used to help alleviate discomfort of arthritis, shingles, eczema, psoriasis and other inflammatory conditions.
Why BioHeal Is Better than Cortisone on Irritated and Damaged Skin
   BioHeal's copper-peptides reduce the need for the use of corticosteroids for skin dermatitis. Corticosteroids (such as cortisone) produce damaged and thinned skin (often 50% thinner) by inhibiting the natural skin repair processes. Use of corticosteroids produces a vicious cycle requiring more corticosteroid use due to more irritations from the weakened skin. The use can promote diabetic conditions, thymus involution, immune suppression, the spread of cancers, bone damage, and cataracts. It is estimated that 5,000 hip replacements yearly in Canada are due to overuse of corticosteroids.
        During inflammation, the skin is damaged by immune cells that release toxic oxygen radicals into the damaged area. The purpose of these oxygen radicals is to kill invading bacteria after wounding but often the oxygen radicals are released in the absence of any bacteria. Cortisone and corticosteroids act by killing the immune cells to stop oxygen radical release but this also kills the immune cells that release the skin repair growth factors and hence stops skin repair which ultimately leads to a thinned and damaged skin.
        Copper-peptides, on the other hand, directly detoxify the oxygen radicals. They also transfer copper to superoxide dismutase (SOD), the skin's primary anti-oxidant protein, which activates the skin's SOD which further increases the removal of oxygen radicals. Also, the copper-complexes have been shown to strongly stimulate the skin's repair systems and improve healing and skin renewal. The above mentioned nickel allergy study demonstrated both the anti-inflammatory and skin repair properties of copper-peptides. (Zhai, Chang, Singh, and Maibach, "In vivo nickel contact dermatitis: human model for topical therapeutics", Contact Dermatitis Vol. 40, pp. 205-208, 1999.)
Comparison: Effect of Copper Peptide vs Corticosteroids 
for Skin Repair and Anti-inflammation
Stops Inflammation by Effect on Skin Repair and Renewal
BioHeal -
Copper-Peptide
1. Detoxifying 
oxygen radicals
2. Activating the skin's superoxide dismutase
Strongly stimulates skin repair and renewal 
Cortisone
& Other Corticosteroids
1. Killing immune cell macrophages and neutrophils 
which secrete 
oxygen radicals
Stops skin repair and renewal by killing macrophages which secrete skin repair growth factors
CP-SERUM, skin rigeneration and glow
cp.jpg (4728 byte)CP Serum is a skin care serum with copper-peptides that helps skin renewal while enhancing the skin's protective barrier and anti-oxidant defenses. Customers have told us that the serum enhances facial beauty and gives an "extra glow". The serum has no lipids and is useful for persons with high skin oil and for use in very warm regions.
        The simple ingredients in the serum make it more acceptable for many persons with very sensitive skin or persons with acne who must limit lipids on their skin.
CP Serum is compatible when used with alpha hydroxy acids and Retin-A « (marchio registrato). CP Serum should not be used at the same time as vitamin C creams since the copper-peptide inactivates the vitamin C. CP Serum ingredients : purified water, hydroxyethylcellulose, copper-peptides (hydrolyzed soy protein chelated to copper chloride), allantoin, diazolinydinyl urea, methylparaben, propylparaben.
How to Use - Renewing Your Skin and Improving Skin Color
      1. Apply a small amount of the CP Serum once or twice daily. Start gradually then increase the amount applied.
        If your skin is very sensitive or already irritated, start with a very light amount of CP Serum every other day for a week. This will allow your skin to re-build its natural skin barrier. Sometimes people with very sensitive skin may have their skin already in a state of sub-clinical inflammation after the use of many different skin-damaging toners, astringents, cleansers and moisturizers.   Then after the initial week, use more CP Serum.  This approach has worked well for many persons with very sensitive skin who have a tendency to have skin reactions. Do not use within 12 hours of using a vitamin C product on your skin.
       Cautions: In some persons, there may exist previously developed skin allergies to common cosmetic ingredients. If you notice severe itching or skin reactions after use of either of the products, discontinue use of the products. The ingredients in CP Serum are non-irritants, non-allergens, and non-comedogenic and have passed numerous safety tests.
 
CP-SERUM NAIL RENEWAL
Ingredients : purified water, aloe vera gel, squalane, octyl palmitate, glycerol stearate, PEG-100 stearate, propylene glycol, cetyl alchol, copper peptides (hydrolyzed soy protein and copper chloride), stearic acid, allantoin, retinol, diazolinydinyl urea, methylparaben, propylparaben, mixed natural tocotrienols, ubiquinone, ergocalciferol, bronopol.
During prolonged rainy periods in Washington States, horses often develop severe irritations in their lower extremities – especially where the hair-covered skin joins to the hooves. This skin area can develop irritations, infections and bleeding. During experiments to heal such irritated skin with creams containing copper peptides, the application of the copper-peptide cream was often imprecise due to movements of the horses and the cream were generously applied to the lower skin of the leg and part of the upper hooves. While the creams were observed to rapidly heal the skin areas, we also unexpectedly observed that damaged hooves appeared to improve markedly in health. Later, we experimented with more controlled application of the copper peptide creams into cracks in badly damaged hooves. We found that the copper peptide cream usually produced a remarkable healing of the hooves and closure of the cracks.
        Since then hooves of horses and the nails of humans are similar in terms of their biochemistry and cellular biology, we tested the application of such copper peptide creams to damaged human fingernails and toenails. We observed that such treatment produced in humans, as in the horses, a remarkable improvement in nail health and growth. Such types of copper-peptides, when applied to the nail matrix and nail bed area, enhance the process of nail growth resulting in stronger, thicker and smoother nails. Such types of copper-peptides have previously been found to strongly enhance the production of the protein collagen and also accelerate the repair of damaged skin. However, since nails are primarily composed of the hard protein keratin, it was not expected that copper-peptides would increase the production of keratin and nail growth.
Effect of CP Nail Renewal on Nail Growth

First Experiment

Sex

Finger Nail Growth with CP Nail Renewal 
(Millimeters in four weeks)

Finger Nail Growth with Placebo cream 
(Millimeters in four weeks)

   

Right Hand

Left Hand

Person 1

M

4.2

2.7

Person 2

M

3.2

2.1

Person 3

F

4.3

3.2

Person 4

F

3.8

2.9

Person 5

F

3.9

2.6

       

Second Experiment 

 

Left Hand

Right Hand

Person 6

M

2.8

1.5

Person 7

M

3.7

2.6

Person 8

F

4.1

3.0

Person 9

F

4.1

2.6

For Stronger, Healthier Nails
1. Before bed, rub a light coating of CP Nail Renewal over your hands and rub onto your nails and cuticle areas. Healthy, strong nails are better than any artificial coating.
2. Avoid prolonged wetting and drying of the fingernails. Nails are strongest when slightly acid. Avoid exposing your nails to harsh chemicals and alkaline conditions.
3. Use your hands or finger pads to do simple chores rather than your nails. Avoid picking up objects when your fingertips may strike a hard surface - instead slide the object off the side into your hand.
4.  Use a pencil to dial a phone, never your finger tips. Use a letter opener, not your fingernail, to open envelopes and packages.
5. Dig your nails into a bar of soap before gardening. This will help prevent dirt from getting under the nails.
6. Always wear rubber gloves when doing dishes or other "tough on the nails" jobs.
Wear regular gloves during cold weather or when doing chores which may injure the nail tips.
7. Manicure your nails regularly since a smooth nail will tear and split less.
8. Shape and file your nails with a very fine file. Round the tips in a gentle curve. If you have snags or irregularities, file them daily to prevent further breakage or splitting.
8. Never use metal instruments to push back the cuticle. The metal scrapes away the protective cells of the nail surface.
9. If your nails are "buffed," always do this in the same direction as the nail grows and never in a "back and forth" motion which can cause nail splitting.
10. If you have severe breakage or tearing problems, nail polish can protect the nail surface. Nail polishes containing nylon fibers can add strength and protection to fragile nails.
11. If your natural nails are fairly long and strong, but tend to break off at a certain length, you may be helped by having a fiberglass overlay applied to them. In this procedure a light layer of fiberglass is brushed over the natural nail. This coating creates a stronger, better protected nail which is less prone to breakage. Fiberglass overlays require re-doing about every two weeks.
11. Use nail polish remover as infrequently as possible since it dries and damages the nails.
12. Daily biotin (2.5 mg a day) may help your nails, but do not add biotin if you are pregnant.
13. Some people feel that one pack of Knox gelatin a day helps their nail health.
 
EMU-OIL, skin moisturizer
Ingredients: peroxide-free emu oil supplemented with ubiquinone, 7-keto DHEA, and mixed tocotrienols
Many skin moisturizers sold by cosmetic companies cause long-term damage to your skin. Traditional skin moisturizers are formulated from a variety of low-cost oils and water-soluble chemicals that wet and loosen the skin's layer of outer protective proteins and also cover the skin with fats that impede water loss. This provides a brief moisturization of your skin but degrades the skin's protective properties against bacteria and viruses. Such moisturizing creams are a mixture of oil and water plus emulsifiers, stabilizers, preservatives and other chemicals. There is little evidence that such creams have any beneficial effect on skin.
Emu Oil-S for Skin is very similar in composition to human skin oils and acts to replenish skin lipids.
Methods of Skin Moisturization
Method How method works Time to be effective Problems 
Copper-Peptides  Mimics natural repair
Repairs skin barrier 
and increases the 
skin's proteoglycans and GAGs
About 2 to 3 weeks None
Waxes and greases Heavy oils such as
petrolatum seal skin surface to water loss
Immediate Greasy
Skin Oils  Light oils such as 
sesame oil seal skin surface to water loss
Immediate Not as durable as waxes and greases
Cosmetic 
moisturizers
Mixtures of oils, water, and surface active chemicals used to open skin barrier and 
hydrate skin proteins 
One day Acts like irritant
Loosens protective skin barrier
Skin more susceptible to infection 
Lipids and fats in the skin provide the epidermal barrier to transcutaneous water loss. These lipids in the upper skin area called the stratum corneum are arranged in layers called lamellae. The lower skin layers contain more typical fats such as triglycerides and phospholipids while the upper layers have more ceramides, cholesterol and free fatty acids.
While lipid replenishment methods are still being developed by dermatological scientists, emu oil is already a very good natural oil for lipid replenishment. It comes from small ostritch-like bird.
Australian aborigines discovered the benefits of emu oil many thousands of years ago and used its helpful properties on damaged and sunburned skin. The fatty acid composition of human skin oil and emu oil are very similar. In both oils, mono-unsaturated oleic acid is the most prevalent, then palmitic acid, followed by the essential fatty acid, linoleic acid. This may be the reason for the positive actions of emu oil on human skin. Skin researchers at the University of Texas Medical School in Houston reported that emu oil at up to 100 % concentration in lotions to be nonallergenic, non-comedogenic, have low irritation potential, and to be bacteriostatic.
While scientific studies on emu oil are just beginning, emu oil has been traditionally used help alleviate discomfort of arthritis, shingles, eczema, psoriasis and other inflammatory conditions.
Replacement of key skin lipids often accelerates skin repair and can be a helpful treatment for dry skin and eczema. Also, conditions such as burns and psoriasis often benefit from emu oil.
EMU OIL S Lipid Replenisher for Skin is a peroxide-free emu oil supplemented with Ubiquinone, 7-keto DHEA, mixed isomers of natural tocotrienols, and mixed isomers of vitamin E.
Tocotrienols and Skin Health
Topically applied tocotrienols selectively accumulate in skin and serve to protect it against ultraviolet damage and oxidation.  (Traber et al 1997). In rats it was found that UV radiation significantly reduced vitamin E concentrations after 29 minutes of UV exposure, but in skin treated with tocotrienols the vitamin E concentrations were 7 to 30-fold higher after the radiation.
7-Keto DHEA and Skin Health
   7-keto DHEA is a safer metabolite of regular DHEA (dehydroepiandrosterone), a natural hormone that improves skin lipid production.   7-Keto DHEA is one of more than 150 metabolites of DHEA , a precursor hormone that is produced by the adrenal gland and source of many other hormones, including the sex hormones estrogen and testosterone. Unlike regular DHEA, 7-Keto DHEA is not converted into either estrogens or testosterone but still has DHEA's other beneficial actions.    In recent controlled studies, 7-keto DHEA has been shown to improve sense of well-being, immune and mental function, and muscle tone in middle aged men and women.
DHEA levels peak at age 25, then gradually decline. By age 60, DHEA levels are 30% or less of those in young adults. DHEA is also essential for proper sebaceous gland functioning and the production of skin oils. Much of the increase of dry skin with age is due to the decease in DHEA levels in the skin. (Sourla et al).
    Schwartz and Pashko (1996) reported that "topical application of DHEA on mouse skin inhibits skin tumor promotion."   DHEA aids the skin's superoxide defense and this may explain its ability to prevent skin cancer and papillomas (benign tumors). DHEA also keeps some chemical carcinogens from binding to DNA. According to researchers at the Fels Research Institute and Temple University, cancers just do not started if enough DHEA is present.
    Studies show that DHEA is readily absorbed by skin when applied topically. Topically applied DHEA helps protect the skin's delicate blood vessels. Researchers reported that when DHEA was applied after a serious burn, the blood vessels underlying the burned area are protected and the skin is retained instead of peeling off.
Ubiquinone and Skin Health
Ubiquinone is an oxidative reduction agent that functions in the energy-producing electron transfer chain in the mitochondria of cells. Ubiquinone also serves as an important lipid-soluble antioxidant in the skin and other organs protecting against free radical damage from peroxides that damage collagen and elastin, which produces a loss of elasticity in the skin and wrinkle formation. Animals fed Ubiquinone have lower cancer rates.  Ubiquinone discoverer, Dr. Karl Folkers suggested that Ubiquinone might control cancer either by facilitating antibody synthesis or by counteracting tumor cell functioning. His ideas were based on case reports of  unexpected or unusually long survival for cancer patients who were using Ubiquinone for cardiac problems.
EXFOL-CREAM,  salicylic acid 2%
Purified water, aloe vera gel, squalane, octyl palmitate, PEG-stearate, glycerol stearate, safflower oil, salicylic acid, stearic acid, cetyl alcohol, allantoin, diazolinydinyl urea, methylparaben, propylparaben, bronopol,mixed (alpha, beta, gamma, delta) tocopherols, mixed (alpha, beta, gamma, delta) tocotrienols, vitamin D.
EXFOL-SERUM,  salicylic acid 2%, without lipids
Purified water, aloe vera gel, salicylic acid, hydroxyethylcellulose, allantoin, polysorbate-20.

If you have acne problems - the best for scar reduction are the lipid-free products - CP Serum with Copper Peptides and Exfol Serum - an aqueous salicylic acid serum.

GENTLE CLEAN, cleanser for very sensitive, damaged skin and valuable skin
Gentle Clean is a cleanser for skin that is sensitive, fragile, dry, itchy, damaged, or valuable skin. The cleanser was specifically formulated to clean the fragile skin of cancer patients after radiation or chemotherapy. Most cleansers cause damage to very fragile and damaged skin. Gentle Clean combination of an effective but very mild cleanser is especially appropriate for persons with dry skin, eczema, allergy-prone skin, psoraisis, diabetes or those recovering from cancer therapy. However, even if your skin is healthy but you consider your skin to be very valuable, this very mild cleanser will help clean and protect your skin.
Gentle Clean was developed as a cleaning agent for very sensitive and damaged skin and has been field tested for four years. Nurses and physicians report that the cleanser works very well on sensitive and fragile skin such as which occurs with eczema, in the bedridden, or after cancer therapy. Some nurses and physicians have told us that they think the cleanser has healing properties but we believe that the very careful preparation of the product produces the good results.
        Many soap and cleansers not only remove surface dirt and oils, but they actually damage the skin by destroying its natural protective "Acid mantle", the skin's lipid and antioxidant barrier. This damage leads to the generation of more skin-damaging free radicals and creates a dry, flaky skin which stimulates the production of more oil.
        Gentle Clean works well for skin cleaning during exfoliation for skin renewal. It is is a good cleaning system for persons as risk for skin damage such as those with eczema, psoriasis, or diabetes. Fragile skin can literally be dissolved by strong soaps.
        The clear, translucent cleansing bars contain no harsh detergents, caustics, glycerin, or "flash" foaming agents. The pH of 7.8 is near neutrality in contrast to the very basic pH of most soap and skin cleansers.
        Customers tell us that the bar works very well to removing mascara and other color cosmetics

GLYCOLIC-8, glycolic acid 8%

PROTECT & RESTORE , renewing your skin's youth
Protect & Restore is the strongest skin regenerating (with published, credible, scientific proof of skin renewal) skin care product available. P&R has is much stronger than the only two other skin regenerating copper peptide product lines available. Protect & pro.jpg (9216 byte)Restore has between 8.8 and 18.7 more skin regenerating copper peptide than various products in the very excellent Neutrogena Visibly Firm skin product line and and ProCyte Neova skin product line.
Skin regenerating copper-peptides aid the skin's mechanisms of skin renewal while enhancing the skin's protective barrier, anti-oxidant defenses, and sun protection. Thousands of customers have told us that the cream enhances facial beauty by stopping breakouts, removing blemishes, improving skin elasticity, firmness, and texture while reducing wrinkles. It also helps to reduce excessive skin redness after the use of retinoic acid or alpha hydroxy acids, and improves their natural skin color (some women say this is an "extra glow"). Protect & Restore often eliminates the need for moisturizers. Four independent, published clinical studies at the University of California have proven that Protect & Restore has both skin repair and anti-inflammatory properties and is hypoallergenic.
P&R Classic Skin Renewal Cream
This cream has a slipping agent to improve the spreadability of the cream.  Women who have had difficulty with creams containing high Retinol and/or Oil of Lavender are reporting good results with this cream.
Product Ingredients: Purified water, squalane, octyl palmitate, glycerol stearate,  PEG-100 stearate, cetyl alcohol, copper-peptides (aqueous mixture of hydrolyzed soy protein and copper chloride), myristyl ether proprionate, stearic acid, allantoin, diazolinydinyl urea, methylparaben, propylparaben, mixed tocotrienols, mixed tocopherols, 7-keto DHEA, coenzyme Q-10.
P&R with High Retinol and Oil of Lavender
  This version has a high level of Retinol and Oil of Lavender and is our most potent skin renewal and anti-wrinkle cream. It is our most re-ordered P&R. Many people say it is the best skin cream they ever used and that the cream rapidly improves skin color and health while stopping acne flare-ups. Several people with unresponsive cystic acne have reported a clearing of long-term acne in a little as one week. It is good for scar ands stretch-mark reduction. On the other hand, in some people the cream can lead to an acne outbreak. In general, do not use this cream if you are under age 25, or have problems with other high Retinol products (such as Neutrogena's "Retinol(TM)") or with Oil of Lavender. Some women who had problems with this cream are reporting very good skin improvement results with the non-retinol P&R versions.
  The oil of lavender has soothing effects on the skin. Oil of Lavender was used on wounds in ancient Greece and Rome over 2,000 years ago. Today it is widely used in clinical wound-treatment products. In one placebo-controlled blinded study of 635 women, it was found that the application of oil of lavender to the outer birth canal resulted in much less pain and discomfort after childbirth. Do not use if you are sensitive to Oil of Lavender.
Product Ingredients: Purified water, squalane, octyl palmitate, glycerol stearate,  PEG-100 stearate, cetyl alcohol, copper-peptides (aqueous mixture of hydrolyzed soy protein and copper chloride), myristyl ether proprionate, stearic acid, allantoin, diazolinydinyl urea, methylparaben, propylparaben, oil of lavender, mixed tocotrienols, mixed tocopherols, 7-keto DHEA, coenzyme Q-10.
P&R Day Cover
   P&R Day Cover is designed as a daytime replacement for sun protective creams with dangerous chemical sunscreens. This cream contains a high level of natural ultraviolet absorbers such as squalane, peptides and nucleotides that have been protecting mammalian skin for over 100 million years. We feel these are far safer than the dangerous chemical sunscreens in cosmetics that cause allergies, skin irritations, and may increase your risk of major cancers. The cream still significantly helps skin repair.
Product ingredients : purified water, squalane, octyl palmitate, glycerol stearate, PEG-100 stearate, cetyl alcohol, myristyl ether proprionate, polypropylene glycol, hydrolyzed soy protein, stearic acid, allantoin, cupric chloride, diazolinydinyl urea, methylparaben, propylparaben, oil of lavender, mixed tocopherols, mixed  tocotrienols, 7-keto DHEA, coenzyme Q-10.
 
Protect & Restore Suntanning Lotion, suntan science, faster, healthier suntanning, without toxic sunscreen
Protect & Restore Suntanning Lotion contains patented (US Patent 5,698,184) copper-peptide complex that acts as a superoxide dismutase that can help de-toxify oxygen radicals produced by ultraviolet rays on the skin's surface. Creams containing superoxide dismutase activity have been proven to help protect skin during ultraviolet radiation exposure.  (Reference: Miyachi Y, Imamura S, Viwa G. Decreased skin superoxide dismutase activity by a single exposure of ultraviolet radiation is reduced by liposomal SOD pre-treatment. J Invest Dermatol 1987; 87:111-2). P&R Suntanning Lotion also contains other anti-oxidants such as vitamin E, tocotrienols and Ubiqunone.
        In addition, the lotion contains titanium dioxide (a reflective sunblocker), and a high level of squalane and other proven skin protective agents such as allantoin, aloe vera, glycerol stearate and octyl palmitate. Squalane is the skin's most important protective lipid and declines from levels of 11% in teenager's skin to less than 5% in adults after age 20. The cream components such as squalane, peptides, and allantoin are all natural skin components that have high absorption in the ultraviolet range to help protect the skin. P&R Suntanning Lotion does not contain chemical sunscreens such as benzophenone or oxybenzone (benzophenone-3) which are free-radical generators and may increase cancer risks.
        The composition of Protect & Restore Suntanning Lotion is: Purified water, aloe vera gel, squalane, octyl palmitate, PEG-100 stearate (glycerol stearate and PEG-100 stearate), polypropylene glycol, cetyl alcohol, copper peptides (hydrolyzed soy protein + copper chloride), myristyl ether proprionate, stearic acid, allantoin, titanium dioxide, diazolinydinyl urea, methylparaben, propylparaben, mixed natural tocopherols (alpha, beta, gamma, delta isomers),  mixed natural tocotrienols (alpha, beta, gamma, delta isomers), 17-keto DHEA, ubiquinone, melatonin, herbal fragrance, retinyl palmitate, ergocalciferol, bronopol. (Copper peptides are formed when the cupric chloride and hydrolyzed soy protein are mixed in water during the preparation of the Suntanning Lotion.)
Tocotrienols and Skin Health
Topically applied tocotrienols selectively accumulate in skin and serve to protect it against ultraviolet damage and oxidation.  (Traber et al 1997). Diet alone cannot supply adequate amounts of tocotrienols for skin protection. In rats it was found that UV radiation significantly reduced vitamin E concentrations after 29 minutes of UV exposure, but in skin treated with tocotrienols the vitamin E concentrations were 7 to 30 fold higher after the radiation.
7-Keto DHEA and Skin Health
   7-keto DHEA is a safer metabolite of regular DHEA. 7-Keto DHEA is one of more than 150 metabolites of DHEA (dehydroepiandrosterone), a precursor hormone that is produced by the adrenal gland and is the source of many other hormones, including the sex hormones estrogen and testosterone. Unlike regular DHEA it is not converted into either estrogens or testosterone but still has DHEA's other beneficial actions.   In recent controlled studies, 7-keto DHEA has been shown to improve sense of well-being, immune, mental function, and muscle tone in middle aged men and women.
DHEA levels peak at age 25, then gradually decline. By age 60, DHEA levels are 30% or less of those in young adults. DHEA is essential for proper sebaceous gland functioning and the production of skin oils. Much of the increase of dry skin with age is due to the decease in DHEA levels in the skin. (Sourla et al).
    Schwartz and Pashko (1996) reported that "topical application of DHEA on mouse skin inhibits skin tumor promotion."   DHEA aids the skin's superoxide defense and this may explain its ability to prevent skin cancer and papillomas (benign tumors). DHEA also keeps some chemical carcinogens from binding to DNA. According to researchers at the Fels Research Institute and Temple University, cancers just do not start if enough DHEA is present.
    Studies show that DHEA is readily absorbed by the skin when applied topically. Topically applied DHEA helps protect the skin's delicate blood vessels. Researchers reported that when DHEA was applied after a serious burn, the blood vessels underlying the burned area are protected and the skin is retained instead of peeling off.
Ubiquinone and Skin Health
Ubiquinone is an oxidative reduction agent that functions in the energy-producing electron transfer chain in the mitochondria of cells. It also serves as an important lipid-soluble antioxidant in the skin and other organs. It  protects against free radical damage from peroxides that damage collagen and elastin, thus protecting against a loss of elasticity in the skin and wrinkle formation. Animals fed ubiquinone have lower cancer rates and its discoverer, Dr. Karl Folkers,  suggested that ubiquinone might control cancer either by facilitating antibody synthesis or by counteracting tumor cell functioning. His ideas were based on case reports of   unexpected or unusually long survival for cancer patients who were using ubiquinone for cardiac problems.
Melatonin and Skin Health
Melatonin is a hormone connected with sleep patterns and also a powerful human antioxidant that protects against UV radiation. Researchers at the University of Zurich have shown that topically applied melatonin gives excellent protection against sunburn if applied before sun exposure and also may have role in repairing burned skin. In small amounts, melatonin causes skin cells to proliferate. People with psoriasis and atopic eczema have low melatonin levels.
The Skin Biology Approach to Sensible Suntanning
1. Before suntanning apply Protect & Restore Suntanning Lotion as a thin coating prior to suntanning. A small amount of water may be used to help spread the cream. This is a skin regenerating cream with titanium dioxide and high levels of anti-oxidants.
2. After suntanning, re-apply P&R Suntanning Lotion or P&R Body Lotion. THIS IS CRITICAL - USE COPPER PEPTIDE SKIN REGENERATING CREAMS BEFORE AND AFTER SUNTANNING.
3. If you have a tendency to sunburn or plan an extended time in the sun, use a reflective sunscreen such as zinc oxide or titanium dioxide. One acceptable sunblocker is Clinique's SPF-25 Special Defense Sunblock which is chemical sunscreen-free.
4. Moderate suntanning ( 30 minutes maximum per day ) over a number of days produces the best results. Suntanning slowly produces pigment (melanin) in the skin. It takes about three days to induce significant melanin in your skin. Melanin blocks ultraviolet rays and also serves as a powerful anti-oxidant. In addition, the skin's natural defenses against oxygen radicals include other anti-oxidants such as Vitamin E and beta-carotene, and the copper-containing protein, superoxide dismutase, all of which de-toxify oxygen radicals and reduce skin damage.
5. Suntanning also thickens the skin and this provides further protection against sun burns but this thickening takes about three weeks. Skin thins with age and is thicker when we are young. But again, go slow!
6. Remember, excessive sun exposure can overwhelm the protective systems in the skin, causing skin damage that produces skin peeling and other types of damage. Dr. Lester Packer (University of  California, Berkeley) has published extensively on the role played by antioxidants such as Vitamin   E and skin protection. His research found that after absorbing in the UVB   radiation from sunlight spectrum, vitamin E is transformed into a free   radical  (tocopheroxyl)  which can regenerate back to vitamin E (tocopherol) via reaction with the skin's vitamin C (ascorbic acid).  Packer's   hypothesis is that as ultraviolet radiation dosage is gradually increased, these two antioxidant defenses of the skin are overwhelmed. Then free radicals begin to form in the skin and cause various types of cellular damage, including lipid peroxidation and oxidative modification of skin proteins and cellular DNA. Packer has measured the depletion of cutaneous lipid soluble antioxidants (such as Vitamin  E) after ultraviolet radiation of the skin. For example, 45 minutes of exposure to the noon-day sun can lower the skin's protective vitamin C levels by 80%. and also markedly lower other protective skin anti-oxidants such Vitamin E and beta-carotene. Packer also finds that sunblockers reduce this depletion of dermal antioxidants.
7. Take 2 milligrams of copper 2+ daily. Do this even if you are taking a multimineral supplement since most such supplements have so much zinc that they drive out copper 2+. The extra copper 2+ will activate more superoxide dismutase, your primary anti-oxidant defense.
The extra copper 2+ will also activate more copper-requiring tyrosinase. The enzyme converts tyrosine into melanin, the skin pigment. It is impossible to effective tan with adequate copper 2+ in your skin.
8. High quality sunglasses that absorb ultraviolet rays should be worn for eye protection.
"Inside-Outside" Sun Protection
         If you tend to sunburn or plan an extended time in sunlight, take anti-oxidant supplements. Studies have found that both the topical application of anti-oxidants and the ingestion of supplemental anti-oxidants reduce sun damage.
         The following supplements have been recommended by skin researchers. (Source: Drug and Cosmetic Industry, September 1997, pages 52-55 and December 1997, pages 40-44.  
Why Protect & Restore Is Better than Cortisone on Irritated Skin
          Protect & Restore's copper-peptide reduces the need for the use of corticosteroids for skin dermatitis. Corticosteroids (such as cortisone) produce damaged and thinned skin (often 50% thinner) by inhibiting the natural skin repair processes. Use of corticosteroids produces a vicious cycle requiring more corticosteroid use due to more irritations from the weakened skin. The use can promote diabetic conditions, thymus involution, immune suppression, the spread of cancers, bone damage, and cataracts. It is estimated that 5,000 hip replacements yearly in Canada are due to overuse of corticosteroids.
        During inflammation, the skin is damaged by immune cells that release toxic oxygen radicals into the damaged area. The purpose of these oxygen radicals is to kill invading bacteria after wounding but often the oxygen radicals are released in the absence of any bacteria. Cortisone and corticosteroids act by killing the immune cells to stop oxygen radical release but this also kills the immune cells that release the skin repair growth factors and hence stops skin repair which ultimately leads to a thinned and damaged skin.
        Copper-peptides, on the other hand, directly detoxify the oxygen radicals. They also transfer copper to superoxide dismutase (SOD), the skin's primary anti-oxidant protein, which activates the more skin's SOD (normally only about 30% of SOD is active) which further increases the removal of oxygen radicals. Also, the copper-complexes have been shown to strongly stimulate the skin's repair systems and improve healing and skin renewal. The above mentioned nickel allergy study demonstrated both the anti-inflammatory and skin repair properties of copper-peptides. (Zhai, Chang, Singh, and Maibach, "In vivo nickel contact dermatitis: human model for topical therapeutics", Contact Dermatitis Vol. 40, pp. 205-208, 1999.)
Protect & Restore
Clinically-proven to speed skin renewal
Rebuilds collagen and elastin for a firmer, more elastic skin
Activates skin remodeling to remove damaged proteins
Activates the skin's natural anti-oxidant defense
Better skin blood circulation improves skin color
Helps reduce irritation from retinoic acid and hydroxy acids
Improves skin uniformity and "glow"
Reduces itching and flaking of the skin
Hypo-allergenic
Will not clog pores
Ultraviolet protection
Anti-inflammatory action
Retinol versions to increase wrinkle reduction
Glycolic-8, Exfol Cream/Serum, Tri-Reduction Glycolic Exfoliator
Gently exfoliates damaged skin
The best of the alpha hydroxy acid for skin renewal
Rebuilds skin collagen and elastin
Removes skin imperfections
Increases skin firmness and elasticity 
Age Range Skin Condition Skin Problems Common 
Treatments
Best P&R choices
18-24 High oil production 
Collagen/Elastin 
  in balance 
Thick elastic skin
Hormonal  Increases 
Rapid skin repair
Skin replaced every 
   three weeks 
Acne from High Oil
Too many cosmetics used
For Acne - Retin-A « (marchio registrato), 
Differin, Accutane
1. Classic - no retinol
25-45 Some Acne
Dryer Skin
Slower skin repair
Collagen/Elastin 
  breakdown starts 
Decreased skin pheromones
Women - eczema from childcare, wrinkles start Retin A
Hydroxy Acids
1. Classic - no Retinol
    Rosacea Antibiotics such as MetroGel and Sulfacet-R
Sometimes Accutane
1. Classic plus 
Gentle Clean
to reduce flare-ups, 
Sometimes eliminates rosacea 
    Chronic Cystic Acne  Retin A 1. High Retinol 
Sometimes Clears Acne
45-70 Thinning Skin
Slower repair 
Collagen/Elastin
  breakdown high
Skin replacement slows to every nine weeks
Decreased skin pheromones
Dry Skin, Wrinkles
Loss of Elasticity
Retin-A « (marchio registrato), Hydroxy Acids
Peels, Laser-Resurfacing
1. High Retinol 
    Skin Lesions Common Remove with Peels, Lasers Remove with mix of 
High Retinol 
and Glycolic-8 applied to lesion
over 70 Thin Skin 
Inadequate Skin Repair
Collagen/elastin 
  breakdown severe
Decreased skin pheromones
Poor healing
Small sores 
  High Retinol 
TRI-REDUCTION, copper peptides to aid in reduction of scars, acne scars, skin tags, stretch marks and sun damage lesion
TriReduction P&R Basic
Ingredients: Purified water, squalane, octyl palmitate, glycerol stearate, PEG-100 stearate, cetyl alcohol, copper peptides (hydrolyzed soy protein chelated to copper chloride), propylene glycol, stearic acid, allantoin,   diazolinydinyl urea, methylparaben, propylparaben, tocopheryl acetate, menthol.
TriReduction P&R with Retinol
Ingredients: Purified water, squalane, octyl palmitate, glycerol stearate, PEG-100 stearate, cetyl alcohol, copper peptides (hydrolyzed soy protein chelated to copper chloride), propylene glycol, stearic acid, allantoin, diazolinydinyl urea, methylparaben, propylparaben, retinol acetate,  tocopheryl acetate, menthol.
TriReduction Glycolic Exfoliator
Product Ingredients - Purified water, glycolic acid (14%), glycerol stearate, PEG-100 stearate, octyl palmitate, safflower oil, stearic acid, cetyl alcohol, sodium hydroxide, methylparaben, propylparaben.
Copper peptides activate the system that removes damaged proteins and scars from the skin.
During skin remodeling, the old damaged protein is removed and replaced with new collagen and elastin fibers. This removes scar tissue and restores skin elasticity and reduces wrinkles.
Exfoliating creams, and their stronger versions used as "chemical peels" have long been used to reduce scars. Likewise, Retin-A « (marchio registrato) (retinoic acid) reduces scars but can be quite irritating to the skin.
The entry of "real" skin repair creams into skin care will also change methods of scar treatment.
        At Skin Biology, we have had many customers report very good results on skin lesion removal or reduction of scars, sun damage marks, skin tags, acne scars, some types of moles and flat warts and stretch marks of pregnancy. Most often the skin repair creams are used in combination with the glycolic acid and/or retinoic acid (Retin-A « (marchio registrato). This is a much lower cost method than laser treatments or silicone sheets and less irritating than retinoic acid alone. This is a very simple, low cost, safe and painless method that often works surprisingly well.
        Dermatologists have long used both glycolic acid and retinoic acid to reduce scars and skin imperfections. The addition of copper-peptide creams improves the overall process.
        Deep chemical peels are often recommended for scars, but if the dermatologist or esthetician is not highly skilled, this is often unsatisfactory and can produce further scarring. We get many telephone calls from people who have had deep chemical peels for scars and ended up with worse scarring than their initial scars or calls about laser treatments that left permanent skin damage.
Use of Copper-Peptide creams with Glycolic Acid and Retinoic Acid
        To use this method to reduce skin lesions, mix the two creams (an exfoliating cream and a copper-peptide skin repair cream) together in a cup or bowl, then apply the mixture to the scar or lesion with your finger. Results should be evident in about one month as a reduction in the area and thickness of the lesion. After a week, you may also notice a slight flaking of skin around the periphery of the lesion. This is usually followed by a shrinking and thinning of the skin lesion which is significant after one month.
        For facial acne scars, either use a mixture of TriReduction P&R Basic or Trireduction P&R with Retinol. If you are under age 25 or have acne flare-ups, stick to TriReduction P&R Basic. With your fingers, just rub a small amount of the cream mixture right on the acne scar.
        Before starting this procedure, make an accurate drawing of the skin lesion(s) on a piece of paper so you can monitor the progress of the treatment.
       If a more active scar removal is desired, add retinoic acid (Retin-A « (marchio registrato) to the mixture or put retinoic acid on the skin lesions in the morning and the mixture of glycolic acid and skin repair cream in the evening.
Scar or Lesion Reduction with P&R (BioHeal), Glycolic Acid, and Retinoic acid 
System Advantages  Problems 
TriReduction P&R Basic and 
TriReduction P&R with Retinol
Reduces many small scars and lesions May need stronger skin renewal 
12 to 15% Glycolic acid creams  Reduces many small scars and lesions May need stronger skin renewal 
20 to 30% Glycolic acid peels More effective scar removal  May cause burns and more scars 
Should be done by experienced dermatologist
Expensive 
Retinoic acid  Reduces many small scars and lesions - Inexpensive  Can be very irritating 
TriReduction P&R creams plus 
TriReduction Glycolic Exfoliation Cream
More effective scar reduction
Inexpensive
None
In morning - 
Use 0.1 to 0.25% retinoic acid 
In evening - use 
TriReduction P&R creams plus 
TriReduction Glycolic Exfoliation Cream
Much more effective scar reduction
Inexpensive 
Can be irritating if overused

Our strongest copper-peptide product cream is TriReduction P&R with Retinol. TriReduction P&R Basic does not have the retinol and is best for areas where acne breakouts may be a problem. If you are under age 25 or have acne flare-ups, then for facial use we recommend using the TriReduction P&R Basic.

Products to Use for Reduction or Removal of Skin Scars and Lesions
Use and person's age Product to Use Comments 
General scar, sun damage and lesion reduction  Use TriReduction P&R with Retinol and TriReduction Glycolic TriReduction P&R with Retinol may cause acne in younger persons
If under age 25, for facial 
scars and lesions 
Use TriReduction P&R Basic and TriReduction Glycolic 
or CP Serum and Exfol Cream/Serum
Many young people (under age 30) 
cannot tolerate Retinol
If over age 25, for facial scars and lesions but problems with breakouts  Use TriReduction P&R Basic and TriReduction Glycolic 
or CP Serum and Exfol Cream/Serum
Best for persons who cannot tolerate Retinol in creams 
Comparison of Scar and Lesion Reduction Methods 

Method of scar reduction

Cost 

Advantages 

Time to Noticeable Improvement

Potential Complications 

Skin regeneration accelerators such as TriReduction $30 to $60 Low Cost
Ease of Use
One Month None
Glycolic/Salicylic acid  $30 to $60  Low Cost
Ease of Use
One Month Mild skin irritation 
Retinoic acid $100 to $300 
($50 to $100 products, 
$50 to $200 dermatologist appointment)
Low Cost
Ease of Use
One Month Skin irritation can be severe
Mixtures of Copper-Peptides, 
Glycolic/Salicylic acid, 
$30 to $60  Better results with less irritation than glycolic acid alone  One Month None 
Mixtures of Copper-Peptides, 
Glycolic/Salicylic acid, 
and retinoic acid 
  Better results with less irritation than glycolic or retinoic acid alone  One Month Mild skin irritation 
Plastic sheets  $100 to $400 for plastic sheets plus 
$200 dermatologist appointment
No pain Two to four months  Modest results - 
takes months
Scar Subcision  $300 to $500 
dermatologist costs
Often works on severe localized scars  Two to four months   
Laser resurfacing  $1,000 to $4,000 Good with
skilled dermatologist 
or esthetician
Two to four months Painful
Local Pigmentation 
More scarring 
Deep peels $500 to $3,000  Good with 
skilled dermatologist 
or esthetician
Two to four months Painful
Local Pigmentation 
More scarring 
Skin Infection 
Dermabrasion  $1,000 to $3,000 Good with 
skilled dermatologist 
or esthetician - 
Sometimes good for deep scars 
Two to four months Painful
Local Pigmentation 
More scarring 
Skin Infection 
Microdermabrasion  $1,000 to $3,000 Good with 
skilled dermatologist 
or esthetician 
Two to four months Milder than dermabrasion - 
Less Painful
Local Pigmentation 
Sometimes scarring 
"At-Home" Skin Renewal Methods
Method Works by  Effects Used Clinically? Problems
Copper-peptides 
(Protect & Restore, 
Blue Copper, 
Neova, A-Copper Moisturizer) 
Triggering the skin's natural renewal mechanisms 1. Rebuilds skin protective barrier 
2. Increases collagen and elastin - more than vitamin C 
3. Increases water-holding proteoglycans 
4. Rebuild blood microcirculation 
5. Activates removal of damaged skin proteins 
6. Activates skin's main antioxidant protein - 
dismutase superoxide
7. Increase apocrine gland size and may increase sexual pheromone attractants
Yes 
1. Wound healing 
2. After skin resurfacing 
3. For hair transplants 
None known
Vitamin C creams and patches Vitamin C helps collagen synthesis and acts as antioxidant 1. Increases collagen production but less than copper-peptides No, effects on skin are too small Must be very acid (pH=2.5) for best effects 
Furfuryladenine creams 
(Kinerase and Kinetin)
Plant chemical that improves skin texture, reduces blotchiness, and reduces fine wrinkles Unknown No None but much less active than copper peptide creams (see below) 
Retinoic acid 
(Retin-A « (marchio registrato)
Acts by irritation and 
cell differentiation actions 
1. Triggers collagen and elastin synthesis but less than copper-peptides 
2. Increases skin thickness 
Yes, for acne and 
skin renewal 
Very irritating 
Produces skin redness
Hydroxy acids Act by irritation 
that stimulates new 
skin repair 
1. Increases collagen and elastin synthesis 
2. Increases skin thickness 
No Effects are slow 
Can be irritating
PRODUCT USE
        We generally recommend starting with P&R Classic.  If you then want more skin renewal and anti-wrinkle activity, try the low Retinol P&R. If these agree with your skin, then try high Retinol P&R  which is our strongest cream and also good for reducing scars and stretch marks. 
        Versions with Retinol which reduces collagen and elastin breakdown which increases after age 30 and increases the wrinkle reduction but also may increase acne outbreaks. Version High Retinol is our most potent cream while Low Retinol has a 90% reduced Retinol content.
        Our records indicate that about 5% of women (mainly under age 30) have difficulty with P&R version High Retinol and this could be as high as 10% because not everyone complains. However, P&R#3 is also our most re-ordered skin cream. Some women who had difficulty with P&R version High Retinol are reporting very good skin results with the non-retinol versions and are recommending these to their friends
        The differences in the versions are actually quite minor but the various versions often have greatly different actions on the skin of different persons. For example, P&R   with Hight Retinol (vitamin A) and Oil Of Lavender has strong skin repair and remodeling properties and works extremely well for some people, but other persons have difficulty with this version.  Also, many people have previous sensitivities to various oils, fragrances, and other cream components. The need for different versions of P&R is similar to the use of different versions of Retin-A « (marchio registrato) or Hydroxy Acids used for people with different skin types.
        In our four clinical studies, we actually ran three different P&R versions through every test but only published data on the standard version. By testing various P&R formulations in this manner, we determined which cream components were critical for skin repair and which were not. For example, we found that various anti-pain agents such as camphor and menthol had no effect on skin repair. Likewise different fragrances had no effect on skin repair. Copper chloride and copper sulfate also make no difference - the copper ion ion the cream is associated with the peptide as a complex. Minor changes in the oil constituents also did not significantly alter skin repair.
In recent months, many of of our customers have told us that they are seeing great results on their skin by applying a thin coating of CP Serum in the morning covered by a small amount of Emu Oil as a moisturizer. Then before bedtime, they apply a thin covering of glycolic/salicylic acid followed by P&R cream.
Post Procedure Treatment after Skin Peels, Dermabrasion, and Laser Resurfacing
1. CP Serum applied to the skin in within 2 hours after the procedure.
2. The client is given a 1 oz vial of CP Serum with instructions to apply a thin coating of CP Serum daily to the healing skin.
3. Caution the client to just use a light coating of CP Serum. Too often, people think more is better.
Post-procedure treatment for skin that remains irritated, reddened, and has new scars from the procedure
In this situation, the treated skin is very sore and irritated. Often burns and hyperpigmentation marks are visible. This state can exist for a year after a procedure.
1. Have the client apply Emu Oil for Skin until the soreness is alleviated.
2. Then have the client apply, to the affected skin, CP Serum followed by Emu Oil on a daily basis.
3. Caution the client to just use a light coating of CP Serum. A small amount of CP Serum is quite effective.
4. Skin recovery by this method is slow but a significant improvement should be noted in a month. For severely burned or irritated skin, full recovery may take several months.
Comparison of Protect & Restore and BioHeal
  The skin repair creams come in two versions but in terms of their skin repair potential they are similar. Protect & Restore is formulated more for cosmetic uses and has a lighter color. Many women use it as a morning make-up base. BioHeal is designed more for therapeutic skin repair and is formulated with non-drug components (menthol and camphor) that help decrease pain and itching. Both versions were tested in the clinical studies and gave similar results on skin repair and reducing irritation.
For skin renewal and repair, Protect & Restore is either used alone or - if stronger skin renewal is desired - with a exfoliating cream such an alpha hydroxy acid like Glycolic-8 or with retinoic acid (Retin-A « (marchio registrato).
Comparison of Protect & Restore, BioHeal, and TriReduction
  The skin repair creams come in three versions but they all increase skin renewal. Protect & Restore is formulated more for cosmetic use and has a lighter color. Many women use it as a morning make-up base. BioHeal is designed more for therapeutic skin repair is formulated with non-drug components (menthol and camphor) that help decrease pain and itching. The TriReduction creams are stronger and designed for "spot" use to help reduce scars, sun damage marks and stretch marks. All versions were tested in the clinical studies and gave fundamentally similar results on skin repair and reducing irritation. 
Moisturizing Skin
        Dry skin is caused by two problems: (1) Damage to the skin's protective barrier which produces excessive water loss through the skin, and (2) a reduction in the concentrations of the skin's water-holding sugars and proteins (proteoglycans and glycosaminoglycans or GAGs). Copper-peptides act by repairing the skin barrier and raising proteoglycans and GAGs. Waxes and oils seal the skin's surface and prevent excessive water loss. Cosmetic moisturizers loosen the skin's protective barrier and hydrate (wet) the skin proteins but at the expense of skin damage.
The essentials of facial skin care are:
1.     A Skin Repair Cream such as Protect & Restore, or Neova (ProCyte)  that both stimulates skin repair and activates the metalloproteases that remove damaged skin proteins. Virtually all other "skin repair" or "night repair" creams on the market are cosmetic company "hype" and have no effects or very minimal effects on skin repair. Any product without independent and published clinical studies - studies that you can readily obtain - should not be purchased.
2.     If you want stronger skin renewal, then use an Exfoliating Cream that uses glycolic/salicylic acid, an alpha hydroxy acid (AHA). AHA's are one of the safest methods of increasing skin turnover. For significant renewal to occur, AHA's must be at least 7% and have a pH (acidity) of 4.0 or lower. Chemical peels with stronger AHA's (70%) speed the process, but the skin rebuilding induced by a 70% AHA chemical peel (which is costly and may cause scarring) in 3 months can be duplicated by a 7% AHA cream in 9 months. The glycolic acid should be at least 7% in concentration and a pH below 4.0. Be cautious with glycolic acid above 10% as it can cause burning. Glycolic acid helps normalize skin oil production.
3.     A Retinoic Acid cream such as generic retinoic acid, Tretinoin, Retin-A « (marchio registrato), or Renova if you have excess skin oil production and acne. Reduce retinoic acid use to fewer times per week if you become too irritated. Retinoic acid is a very good product, but many dermatologists sell the product and tend to over prescribe retinoic acid and under estimate irritation. Never use cortisone or corticosteroids to reduce retinoic acid irritation. Many users of Protect & Restore have told us that it helped reduce the irritation produced by retinoic acid.
        Retinoic acid is the acid version of vitamin A or retinol. It reverses aging effects on skin, reduces wrinkles and mottled darkened spots and smoothes the skin. It reduces skin oil by shrinking sebaceous glands and unclogging follicles. It also increases epidermal thickness and stimulates the deposition of new collagen. Like AHAs, retinoic acid acts by inducing a controlled irritation in the skin followed by the body repairing the damaged area
        Many new versions of Retin-A « (marchio registrato) are now appearing on the market and sold as great improvements over Retin-A « (marchio registrato) (retinoic acid). This is because the patents on Retin-A « (marchio registrato) are expiring which will sharply drop the price. If retinoic acid becomes an OTC product available on the shelf in drugstore, the price will drop to $1 to $2 per tube. The new retinoic acid products appearing on the market are only marginally better (if at all) than the original Retin-A « (marchio registrato) and are being introduced to keep a high price on the product.
4.     A Very Gentle Facial Cleanser. Be careful here because many "gentle" cleansers have very alkaline pHs of 9.5 to 10.0. The pH should be near neutrality and there should be no foaming or lathering agents in the cleanser. These foaming chemicals only damage skin and do not help with skin cleansing. Check out our Gentle Clean Cleansing Bar in this website.
        Also, excessively strong cleansers may wash away your sexual pheromones which are a major component of your attractiveness to others.
5.     For Sun Protection, use products with reflective sunblockers such as pure titanium dioxide and zinc oxide. Do not use micronized or siliconized titanium dioxide or zinc oxide because they penetrate deeply into the skin whereas, the pure forms remain on the skin's surface.
For decades, irresponsible cosmetic companies and a small group of very vocal, publicity-seeking, dermatologists have strongly advocated that chemical sunscreens should be heavily applied before any exposure to sunlight. They insisted that such sunscreen use would prevent skin cancer and protect your health. This was despite of a lack of any adequate safety testing of these chemicals. (It should be emphasized that most dermatologists are much more cautious and careful.
But do not use cosmetics with chemical sunscreens since they are irritating, cause skin allergies, generate free radicals that damage skin, and may cause cancer and birth defects. In 1997, Europe, Canada, and Australia changed sunscreens to use three specific active sunscreen ingredients -avobenzone (Parsol 1789), titanium dioxide, and zinc oxide - as the basis of sunscreens. In the USA, the cosmetic companies have held off this policy as they try to sell off their stockpiles of cosmetics containing sunscreens banned in other countries. Many scientists have presented evidence that chemical sunscreens may increase your risk of cancers of the breast, ovaries, prostrate and colon.
Many common sunscreen chemicals have estrogen-like effects. Such effects can increase cancers, cause birth defects in children, and lower sperm counts in men. Margaret Schlumpf from the Institute of Pharmacology and Toxicology at the University of Zurich, Switzerland, found that they trigger developmental abnormalities in rats. Her research team tested six common UV screening chemicals used in sunscreens, lipsticks and other cosmetics. All five tested UVB screens -benzophenone-3, homosalate, 4-methyl-benzylidene camphor (4-MBC), octyl-methoxycinnamate and octyl-dimethyl-PABA - acted like estrogen in lab tests and caused cancer cells grow more rapidly. One of the most common sunscreens, 4-MBC, when mixed with olive oil and applied to rat skin, caused a doubling of the rate of uterine growth well before puberty. "That was scary, because we used concentrations that are in the range allowed in sunscreens," said Schlumpf. 
5. Your Color Cosmetics for facial color. Use the bare minimum that you need. They are filled with coloring agents and metals that do nothing good for skin.
6. Give Your Skin a Break once a week and use nothing.
7. What Not to Use:   Cosmetic companies want you to pile layers of their products on your skin. Keep in mind that children have great skin and use nothing.
        Moisturizers should be used only as needed since they tend to loosen the outer skin layer. If you use Protect & Restore, you will have a greatly reduced need for moisturizers.
        Toners and astringents may be used for removing makeup but remember that they damage skin and increase skin oil production. Instead, try to use very mild cleansers for makeup removal and facial cleaning.
        Do not use products containing animal collagen or elastin. They have no positive effect on skin and only increase your chances of infection by prions that produce "Mad Cow Disease" and other degenerative diseases.
        Most botanicals and herbs also possess many irritants, poisons, and carcinogens. This is how they reduce their chances of being eaten by insects and other animals. The beauty of a plant or flower has nothing to do with your skin's health.
 
GLYCOLIC ACID
The hydroxyacids are non toxic substances found in the human body, in the fruit, in the wine, in the milk, in the sugar reed, etc. They act as a peeling and powerfully against the wrinkles, antiage.

The alpha-hydroxy-acids include the glycolic acid, lactic, malic, hydroxyicaprylic, hydroxyetanoic, etc.

The beta-idroxy-acids include the salicilic acid, citric acid.

This type of substances accelerate the turnover of the skin, remove the lesions, restore steadiness, elasticity and have "true" moisturizing characteristics, since they the inside.

They not only accelerate the cellular exchange or  remove the dead cells as it often hails the pharmaceutical industry but they improve the renewal of the skin strongly, increasing the collagen, elastin and the inside hydration, stimulating the production of proteins moisturizers and sugars, act as a peeling and powerfully against the wrinkles, as a antiage.

The glicolyc acid is an alpha-idroxy-acid, in fact introduces a idrossilic group tied up OH to the adjacent to carbon the group sour COOH.

The linear formula of glicolyc acid is CH2(OH)COOH.

It has the lowest weight between alpha-idroxyacid and therefore it has more deep and complex action on the skin.

It can be used for improving the penetration of substances through the derma.

It is used mainly for anti-wrinkle effect: it opposes the aging of the skin, with the use the derma returns to have the thickness and turgidity of that of a juvenile. It stimulates the fibroplast directly and therefore the collagen, elastin and mucopolisaccaridi that maintain the young and elastic skin. Although it is an exfoliant, in time great thickness will be had, in fact being igroscopyc (it absorbs water) it develops intense moisturizing action, act as a peeling and powerfully against the wrinkles, as a antiage.

It is always necessary to ask the personal dermatologist.

It is dissuaded for labial herpes. Whom has used the tretinoin it has to attend at least 60 days before beginning the treatment, because the retinoic acid amplifies notably the desire cutaneous reactions.

The effect varies according to the acidity, of the concentration, and from the minutes of laying: more they are tall more it penetrates in depth.

The concentration surest of the glicoly acid seems to be 7-8% to pH 3.5 - 4. Produced to small concentration and superior pH they are ineffective.

After having washed face and removed the sebo from the skin using a gauze dampened with alcohol in non excessive way and without rubbing. Then it is applied with a brush or a coton fioc, therefore it is vaporized on the part water alcalinizzata. To avoid iperacid burns, applies each other to a partial neutralization with trietanolammina or ammonia up to pH 3.5-4.5%, or bicarbonate of sodium at 5%. Therefore it is washed abundantly with water. Then to apply creams to facilitate the reconstruction of the skin and from the soothing effect. An allantoine ointment can be useful.

It causes redness and cutaneous irritation to the moment of the application. Then in the 24-48 following hours  can appear a light desquamation. The redness can have covered with a good cream dye.

The glicolyc acid at 50% collided not with well (ph <1) for over 3 minutes, cause burns of 2║.

SALICYLIC ACID
Such types of copper peptides work best inconjuction with a beta hydroxy acid such as salicylic acid. The hydroxy acid loosens the scar proteins and the copper peptides help in the removal of the scar proteins. The copper peptides also help the process of rebuilding new collagen and elastin into the skin. Biologically effective copper-peptides help the skin to (1) regenerate new collagen and elastin which improve skin firmness and elasticity, (2) increase the production of water holding glycosaminoglycans which is true moisturization, (3) improve the skin’s blood vessel microcirculation, (4) produce biochemical energy from nutrients in the body’s blood supply, (5) increase the natural defense mechanism against oxidative damage, and (6) repair damage to the protective skin barrier.

A leading dermatologist, Dr. Albert Kligman, believes that BHAs, in particular salicylic, at concentrations of about 2%, are better than AHAs for anti-aging and for skin exfoliation. Professor Kligman is well known in dermatology for his research on the anti-aging actions of retinoic acid (Retin-A « (marchio registrato). Results from Dr. Kligman's laboratory found that the outermost stratum corneum layer is renewed after applications of salicylic acid.

A small amount of the salicylic acid is converted into copper salicylate, a powerful and safe anti-inflammatory.  This blends skin exfoliation with skin soothing actions. Salicylate also has ultraviolet absorbing properties. Prof. John Sorenson has researched and written extensively on beneficial actions of copper salicylate on skin, general health, and the anti-cancer properties of copper salicylates.

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