Copper-peptides - in every comparative
clinical study - have been proven superior to Retin-A(R), Vitamin C creams, and
Kinerase(R) in terms of wrinkle reduction, reducing skin blotchiness, improving skin
firmness, and the development of new collagen.
CP Serum is a skin care serum with copper-peptides that helps skin renewal while enhancing the skin's protective barrier and anti-oxidant defenses. Customers have told us that the serum enhances facial beauty and gives an "extra glow"). The serum has no lipids and is useful for persons with high skin oil and for use in very warm regions.
The simple ingredients in the serum will be it more acceptable for many persons with very sensitive skin or persons with acne who must limit lipids on their skin.
CP Serum
was invented by Dr. Loren Pickart and is the best and most effective version of his highly successful Iamin-based peptide-copper tissue regeneration technology.CP Serum Ingredients
Item 130 - Product Ingredients: Purified water,
hydroxyethylcellulose, copper-peptides (hydrolyzed soy protein chelated to copper
chloride), allantoin, diazolinydinyl urea, methylparaben, propylparaben.
How to Use - Renewing Your Skin and Improving Skin Color
1. Apply a small amount of the CP Serum once or twice daily. Start gradually then increase the amount applied.
If your skin is very sensitive or already irritated, start with a very light amount of CP Serum every other day for a week. This will allow your skin to re-build its natural skin barrier. Sometimes people with very sensitive skin may have their skin already in a state of sub-clinical inflammation after the use of many different skin-damaging toners, astringents, cleansers and moisturizers. Then after the initial week, use more CP Serum. This approach has worked well for many persons with very sensitive skin who have a tendency to have skin reactions.
Copper-peptides are used clinically for wound healing, increased skin healing after laser resurfacing and chemical peels, and for improving the success of hair transplantation. They help stimulate the skin's regenerative processes which repair the skin's protective outer barrier, increase new capillary formation (angiogenesis), increase the production of collagen, elastin which improve skin elasticity and firmness, and the increase the water-holding proteoglycans and glycosaminoglycans (GAGs) which hold moisture in the skin and are the only "true" moisturization of skin. They also activate the skin's system (called metalloproteinases) that removes damaged proteins such as in scars and sun damage marks.
Copper-peptides also improve the skin's anti-oxidant defenses by activating superoxide dismutase (SOD), a protein which de-toxifies free radicals and that is the body's primary anti-oxidant defense. Normally SOD lacks enough copper to be active and copper-peptides, by supplying nutritional copper to SOD, increase the activity of SOD.
When copper-peptides are applied to the skin, only very small amounts of the copper-peptides penetrate into the skin. Copper-peptides have passed numerous safety tests. Scientific studies of copper-peptides have found that the amount of copper taken into the body from such copper-peptide creams is insignificant and does not raise total blood copper levels. However, the microscopic amount of copper-peptide that does enter the skin's upper layer is sufficient to help stimulate skin regeneration.
| Method | Works by | Effects | Used Clinically? | Problems |
| Copper-peptides (CP Serum, Protect & Restore, Blue Copper, Neova, A-Copper Moisturizer) |
Triggering the skin's natural renewal mechanisms | 1. Rebuilds skin protective barrier
2. Increases collagen and elastin - more than vitamin C 3. Increases water-holding proteoglycans 4. Rebuild blood microcirculation 5. Activates removal of damaged skin proteins 6. Activates skin's main antioxidant protein - dismutase superoxide 7. Increase apocrine gland size and may increase sexual pheromone attractants |
Yes 1. Wound healing 2. After skin resurfacing 3. For hair transplants |
None known |
| Vitamin C creams and patches | Vitamin C helps collagen synthesis and acts as antioxidant | 1. Increases collagen production but less than copper-peptides | No, effects on skin are too small | Must be very acid (pH=2.5) for best effects |
| Furfuryladenine creams (Kinerase and Kinetin) |
Plant chemical that improves skin texture, reduces blotchiness, and reduces fine wrinkles | Unknown | No | None but much less active than copper peptide creams (see below) |
| Retinoic acid (Retin-A) |
Acts by irritation and cell differentiation actions |
1. Triggers collagen and elastin synthesis
but less than copper-peptides 2. Increases skin thickness |
Yes, for acne and skin renewal |
Very irritating Produces skin redness |
| Hydroxy acids | Act by irritation that stimulates new skin repair |
1. Increases collagen and elastin
synthesis 2. Increases skin thickness |
No | Effects are slow Can be irritating |
| Improvement in skin texture | Reduction in blotchiness | Reduction in fine wrinkles | Source of Data | |
| Copper-peptide cream | 91% positive in 8 weeks | 58% reduction in 8 weeks | 62% decrease in 8 weeks | Data published by Procyte Corporation |
| Furfuryladenine creams | 55% positive in 24 weeks | 38% reduction in 24 weeks | 40% decrease in 24 weeks | J. L. McCullough, in Development of topical Skin Treatments. Skin & Allergy News Supplement 1999. |
Ingredient |
Biological Activity |
Effect on skin |
| Copper-peptides - Skin Biology has five US patents on this technology |
Increases activity of skin
metalloproteinases (Copper-peptides are the only known activator of this activity) |
Removes skin proteins damaged by sunlight,
oxygen radicals or sugar cross links - Removal allows deposition of new collagen and elastin |
| Increases biosynthesis of new collagen and elastin | Tightens and firms skin | |
| Increases production of proteoglycans
and glycosaminoglycans |
Increases the skin's internal moisturization |
|
| Activates the skin's superoxide dismutase
- Increases the skin's ability to de-toxify oxygen radicals in water areas of skin |
Reduces damage from sun environmental pollutants | |
| Repairs and tightens skin barrier | Skin become more resistant to irritants and allergens | |
| Allantoin | Improves skin repair | Helps general skin repair |
A line of products is sold on Value Vision on television called Trace Elements. They say that their colorless copper is superior to copper products that are blue or green. They also say that the blue or green copper products are bad for your skin. However, this is exactly opposite to numerous studies on the use of copper peptides for skin repair and renewal.
Colorless copper is copper ion (+1) and has never been found to have significant skin renewal effects. Copper products that are blue or green are based on copper ion (+2) which is blue in water and produces products that are either blue or green depending how they are mixed with other ingredients.
The only copper form that the FDA allows for clinical use on wounds and skin transplants is the blue form of copper. All the numerous studies from Universities around the world that found positive effects on skin repair and tissue regeneration used the blue form of copper. The natural activator of skin repair in the human body, Gly-His-Lys-Copper(II), has the blue form of copper.
Avoid Skin Oxygenating Products
Certain cosmetic products are sold to increase skin oxygenation. This is done either by (1) covering the face with a mask and running a flow of pure oxygen over the face for about an hour, or (2) covering the skin with certain chemicals that carry extra oxygen into the skin. If skin is damaged, this method may cause an improvement in skin in a few days.
The problem with this method is that it will cause long-term skin problems. By artificially increasing the oxygen level in your skin, your body will decrease the blood vessels (capillaries) that feed oxygen and nutrients to the cells of your skin. Capillaries grow towards areas of the body that are low in oxygen. By adding more oxygen to the outer layers of your skin, your cells will have less oxygen and nutrients from your body. Your skin will age faster because of inadequate nutrients from the blood and your skin will be more pale and grayish because of fewer red blood cells in your skin.
Companies that sell these products say that oxygen applied to the skin has been used to heal wounds faster in hospital studies. This is true, but these types of wounds and skin ulcers are temporary and emergency therapies to heal over the wound and reduce the chance of infection. Long-term application of high oxygen to your skin's surface will not heal the health of normal skin.
Gerontologists consider the cellular degeneration caused by chronic exposure to elevated concentrations of oxygen (hyperoxia) as a model for accelerated aging at the cellular level. In cultured mammalian cells, elevated oxygen causes progressive growth inhibition, loss of reproductive capacity, and chromosomal breakage. The earliest effect of high oxygen is an inhibition of mitochondrial respiration which is in similar to aging theories that attribute much cellular aging to loss of mitochondrial functions. (Pruijn et al 1992)
