Integratore antivirale
antivirus
E' un prodotto di
International Health-Care.
E' un integratore erboristico a base di Puro
Estratto secco di radice di Scutellaria Baicalensis Georgi titolato in
Bioflavonoidi >95%, con proprietà antivirali (inibisce tra
l'altro il virus dell'influenza A e B).
Le proprietà antivirali della
della Scutellaria Baicalensis Georgi
sono bel conosciute, come riportato ad esempio su
http://www.herbmed.org e
http://www.drugdigest.com.
Questa pianta avrebbe inoltre proprietà
antivirali contro il virus HIV, proprietà antifungine (candida) e
potenti proprietà antivirali contro il virus influenzale di forma A
e B, come riportato ad esempio nei seguenti estratti di studi scientifici :
1:
Cell Mol Biol Res.
1993;39(2):119-24.
Inhibition of HIV infection by baicalin--a
flavonoid compound purified from Chinese herbal medicine.
Li BQ, Fu T, Yan YD, Baylor NW, Ruscetti FW, Kung HF.
Biological Carcinogenesis and Development Program,
Program Resources Inc./DynCorp, National Cancer Institute-Frederick
Cancer Research and Development Center, MD 21202-1201.
Baicalin (BA), (formulated as 7-D-glucuronic
acid-5,6-dihydroxy-flavone), was purified from the plant Scutellaria
Baicalensis Georgi. It has been used as a traditional Chinese herbal
medicine. The inhibitory effect of BA against human immunodeficiency virus
(HIV-1) infection and replication has been studied in vitro. The compound
inhibits HIV-1 infection and replication as measured by: (1) a quantitative
focal syncytium formation on CEM-ss monolayer cells; and (2) HIV-1 specific
core antigen p24 expression and retroviral reverse transcriptase (RT)
activity in the HIV-1-infected H9 cells. We have further demonstrated that
the enzymatic activity of purified recombinant HIV-1/RT was inhibited by BA.
In addition to lymphoid cell lines, the anti-HIV-1 activity of BA was also
observed in cultures of primary human peripheral blood mononuclear cells
infected with HIV-1 in vitro. Neither cytotoxic nor cytostatic effects on
the indicator cells were found under the assay condition. This data suggests
that BA may serve as a useful drug for the treatment and prevention of HIV
infections.
PMID: 7693133 [PubMed - indexed for MEDLINE]
- 1:
Ann Pharm Fr.
1995;53(3):138-41.
- [Antifungal activity in vitro of Scutellaria
baicalensis Georgi upon cutaneous and ungual pathogenic fungi]
- Yang D, Michel D, Bevalot F, Chaumont JP,
Millet-Clerc J.
- Laboratoire de Pharmacie
Galénique, Faculté de Médecine et de Pharmacie,
Université de Franche-Comté, Besançon.
- The root of Scutellaria baicalensis Georgi (Lamiaceae) is one of the traditional drugs commonly used in the Far East. The extracts obtained by the successive exhaustion in chloroform and in ethyl acetat present clear fungistatic activities in vitro against to some cutaneous and ungual pathogenic fungi, and particularly upon strains of Candida albicans, Cryptococcus neoformans and Pityrosporum ovale. For each of these, its minimum inhibitory concentration is determined. The ethyl acetat extract appears the most interesting because of its efficiency and of its stability. An antifungal substance is found out as the baicalein.
- PMID: 7677396 [PubMed - indexed for MEDLINE]
-
- 1:
Biol Pharm Bull.
1995 Feb;18(2):295-9.
Antiviral activity of plant flavonoid,
5,7,4'-trihydroxy-8-methoxyflavone, from the roots
of Scutellaria baicalensis against influenza A
(H3N2) and B viruses.
- Nagai T, Suzuki Y, Tomimori T, Yamada H.
- Oriental Medicine Research Center, Kitasato
Institute, Tokyo, Japan.
- We investigated effects of
isoscutellarein-8-methylether
(5,7,4'-trihydroxy-8-methoxyflavone, F36) from the roots of
Scutellaria baicalensis on the single-cycle replication of
mouse-adapted influenza viruses A/Guizhou/54/89 (H3N2 subtype)
and B/Ibaraki/2/85 in Madin-Darby canine kidney (MDCK) cells.
The agent suppressed replication of these viruses from 6 to 12 h
after incubation in a dose-dependent manner by 50% at 20 microM
and 90% at 40 microM, respectively. F36 (50 microM) reduced the
release of B/Ibaraki virus in the medium by 90-93% when it was
added to the MDCK cells at 0 to 4 h after incubation. The
cell-associated virus determined by sialidase activity was also
reduced by the treatment at 0 to 4 h. F36 (120 microM) inhibited
the low pH-dependent membrane fusion of both the viruses with
the liposome containing mixed gangliosides from bovine brain.
However, the agent little affected the hemagglutination and
RNA-dependent RNA polymerase activities of these viruses in
vitro. These results suggest that F36 inhibits the replication
of A/Guizhou and B/Ibaraki viruses at least partly by inhibiting
the fusion of viral envelopes with the endosome/lysosome
membrane which occurs at the early stage of the virus infection
cycle. F36 (0.5 mg/kg) showed no antiviral activity against A/Guizhou
and B/Ibaraki viruses in mice when administered intranasally 5
min prior to virus inoculation, whereas it significantly
inhibited their proliferation in the mouse lung when
administered intranasally 7 times (total 3.5 mg/kg) from 18 h
before to 54 h after virus infection.
- PMID: 7742801 [PubMed - indexed for MEDLINE]
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Risultati in vitro anti HIV
